Proventil 2mg Tablets
Overview
What is this medicine?
How to Use This Medicine
To use this medication correctly, follow your doctor's instructions and read all the information provided. You can take this medication with or without food.
Storing and Disposing of Your Medication
Store your medication at room temperature, away from light and moisture. Keep it in a dry place, avoiding storage in a bathroom. Ensure that all medications are kept in a safe location, out of reach of children and pets. When disposing of unused or expired medication, do not flush it down the toilet or pour it down the drain unless instructed to do so. Instead, consult your pharmacist for guidance on proper disposal. You may also want to check if there are drug take-back programs available in your area.
Missing a Dose
If you take this medication regularly, take a missed dose as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time or take extra doses. If you use this medication as needed, do not take it more frequently than directed by your doctor.
Lifestyle & Tips
- Do not exceed the prescribed dose, as this can increase side effects.
- Report any worsening of breathing or symptoms immediately to your doctor.
- Avoid smoking, as it can worsen respiratory conditions and reduce the effectiveness of the medication.
- Maintain good hydration to help thin mucus in the airways.
Available Forms & Alternatives
Available Strengths:
Generic Alternatives:
Dosing & Administration
Adult Dosing
Condition-Specific Dosing:
Pediatric Dosing
Dose Adjustments
Renal Impairment:
Hepatic Impairment:
Pharmacology
Mechanism of Action
Pharmacokinetics
Absorption:
Distribution:
Elimination:
Pharmacodynamics
Safety & Warnings
Side Effects
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood pressure, including:
+ Severe headache
+ Dizziness
+ Fainting
+ Changes in eyesight
Signs of low potassium levels, such as:
+ Muscle pain or weakness
+ Muscle cramps
+ Abnormal heartbeat
Signs of a severe skin reaction (Stevens-Johnson syndrome, erythema multiforme), including:
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Skin reaction that resembles rings
+ Red or irritated eyes
+ Sores in the mouth, throat, nose, or eyes
Chest pain or pressure
Rapid or irregular heartbeat
This medication may also cause severe breathing problems, which can be life-threatening. If you experience trouble breathing, worsening breathing, wheezing, or coughing, especially after using an inhaler or liquid for breathing in, seek medical help immediately.
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you notice any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:
Feeling nervous and excitable
Dizziness or headache
Upset stomach or vomiting
Shakiness
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe or worsening shortness of breath
- Chest pain or discomfort
- Fast or irregular heartbeat (palpitations)
- Severe dizziness or lightheadedness
- Unusual muscle weakness or cramps (signs of low potassium)
- Allergic reaction symptoms (rash, itching, swelling, severe dizziness, trouble breathing)
Before Using This Medicine
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you are currently taking another medication similar to this one. If you are unsure, consult your doctor or pharmacist to determine if there are any potential interactions.
This list is not exhaustive, and it is crucial to discuss all your medications and health conditions with your doctor. Provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your existing health problems
This information will help your doctor determine if it is safe for you to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor to ensure your safety.
Precautions & Cautions
If you find that your usual dose is not providing adequate relief, your symptoms are worsening, or you need to use this medication more frequently than prescribed, contact your doctor immediately.
If you have diabetes (high blood sugar), it is crucial to closely monitor your blood sugar levels while taking this medication.
Before taking this medication, inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding. Your doctor will discuss the potential benefits and risks of using this medication during pregnancy or breastfeeding to ensure the best possible outcome for you and your baby.
Overdose Information
Overdose Symptoms:
- Tachycardia (fast heart rate)
- Palpitations
- Arrhythmias
- Tremor
- Nervousness
- Headache
- Nausea
- Vomiting
- Hypokalemia
- Hyperglycemia
- Metabolic acidosis
What to Do:
Seek immediate medical attention. Call 911 or Poison Control at 1-800-222-1222. Treatment is supportive and symptomatic, including careful monitoring of cardiac function, serum potassium, and blood glucose.
Drug Interactions
Major Interactions
- Non-selective beta-blockers (e.g., propranolol, nadolol)
- MAO inhibitors (MAOIs)
- Tricyclic antidepressants (TCAs)
Moderate Interactions
- Diuretics (loop or thiazide)
- Digoxin
- Other sympathomimetics
Monitoring
Baseline Monitoring
Rationale: To establish baseline lung function and assess severity of respiratory disease.
Timing: Prior to initiation of therapy.
Rationale: Albuterol can cause cardiovascular stimulation.
Timing: Prior to initiation of therapy.
Rationale: Albuterol can cause transient hypokalemia.
Timing: Prior to initiation, especially in patients at risk (e.g., on diuretics).
Rationale: Albuterol can cause transient hyperglycemia, especially in diabetic patients.
Timing: Prior to initiation, especially in diabetic patients.
Routine Monitoring
Frequency: Periodically, as clinically indicated (e.g., every 3-6 months for stable patients, more frequently for unstable).
Target: Improvement from baseline, individualized.
Action Threshold: Lack of improvement or worsening indicates need for re-evaluation of therapy.
Frequency: Periodically, especially during dose titration or if symptoms of cardiovascular stimulation occur.
Target: Within normal limits or patient's baseline.
Action Threshold: Persistent tachycardia (>100 bpm) or significant hypertension may require dose adjustment or discontinuation.
Frequency: Periodically, especially in patients at risk for hypokalemia (e.g., concomitant diuretic use, severe asthma exacerbation).
Target: 3.5-5.0 mEq/L.
Action Threshold: Hypokalemia (<3.5 mEq/L) may require potassium supplementation or dose adjustment.
Frequency: Periodically, especially in diabetic patients.
Target: Individualized glycemic targets.
Action Threshold: Persistent hyperglycemia may require adjustment of diabetes medication or albuterol dose.
Symptom Monitoring
- Tremor
- Nervousness
- Palpitations
- Headache
- Dizziness
- Muscle cramps
- Chest pain
- Worsening shortness of breath (paradoxical bronchospasm)
Special Patient Groups
Pregnancy
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Studies in animals have shown adverse effects, but there are no adequate and well-controlled studies in pregnant women. Oral albuterol may inhibit uterine contractions.
Trimester-Specific Risks:
Lactation
Albuterol is excreted in human milk. While the amount is likely small, caution should be exercised when albuterol is administered to a nursing mother. Monitor the infant for signs of beta-adrenergic effects (e.g., irritability, poor feeding, tremor).
Pediatric Use
Oral albuterol is approved for children 6 years and older. Dosing must be carefully adjusted based on age and weight. Younger children may be more susceptible to systemic side effects. Inhaled albuterol is generally preferred for acute bronchospasm in children due to faster onset and fewer systemic effects.
Geriatric Use
Elderly patients may be more sensitive to the effects of sympathomimetics, particularly cardiovascular effects (e.g., tachycardia, arrhythmias, hypertension). Start with the lower end of the dosing range (e.g., 2 mg three or four times daily) and titrate cautiously based on response and tolerability. Monitor closely for adverse effects.
Clinical Information
Clinical Pearls
- Oral albuterol has a slower onset and longer duration of action compared to inhaled albuterol, and is associated with more systemic side effects (e.g., tremor, nervousness, tachycardia).
- It is generally reserved for patients who cannot use inhaled formulations or for whom inhaled therapy is insufficient.
- Patients should be advised not to use oral albuterol for acute relief of bronchospasm; inhaled short-acting beta-agonists (SABAs) are the preferred rescue medication.
- Paradoxical bronchospasm, though rare with oral forms, can occur and requires immediate discontinuation.
- Educate patients on the difference between oral and inhaled albuterol and their respective roles in asthma/COPD management.
Alternative Therapies
- Inhaled short-acting beta-agonists (e.g., albuterol HFA, levalbuterol HFA)
- Inhaled long-acting beta-agonists (LABAs) (e.g., salmeterol, formoterol)
- Inhaled corticosteroids (ICS)
- Combination ICS/LABA inhalers
- Long-acting muscarinic antagonists (LAMAs) (e.g., tiotropium)
- Oral corticosteroids (for acute exacerbations)
- Methylxanthines (e.g., theophylline - less common due to narrow therapeutic index)