Polyeth Glycol 3350 Nf Powder 119gm
It is used to treat constipation.
Drug Class
Laxative
Pharmacologic Class
Osmotic Laxative
Pregnancy Category
Not formally assigned, generally considered low risk due to minimal systemic absorption, often cited as Category C by some sources.
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Polyethylene Glycol 3350 is a laxative that works by drawing water into your intestines. This softens your stool and makes it easier to have a bowel movement. It's used to treat occasional constipation.
How to Use This Medicine
Taking Your Medication Correctly
To use this medication properly, follow your doctor's instructions and read all the information provided. When preparing your dose, mix the powder with 1/2 to 1 cup (120 to 240 ml) of a liquid, such as water, juice, soda, coffee, or tea. Stir well to ensure the powder is fully dissolved before drinking. Do not consume the mixture if you notice any clumps. Avoid mixing the powder with starch-based thickeners. Use only the dosing cap that comes with the powder to measure your dose accurately.
Storing and Disposing of Your Medication
Store your medication at room temperature in a dry place, avoiding the bathroom. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of your medication, consult your pharmacist. You may also want to check if there are drug take-back programs available in your area.
Managing Missed Doses
If you take this medication on a regular basis and miss a dose, take it as soon as you remember. However, if it's close to the time for your next scheduled dose, skip the missed dose and resume your normal dosing schedule. Do not take two doses at the same time or take extra doses. If you take this medication as needed, do not take it more frequently than directed by your doctor.
To use this medication properly, follow your doctor's instructions and read all the information provided. When preparing your dose, mix the powder with 1/2 to 1 cup (120 to 240 ml) of a liquid, such as water, juice, soda, coffee, or tea. Stir well to ensure the powder is fully dissolved before drinking. Do not consume the mixture if you notice any clumps. Avoid mixing the powder with starch-based thickeners. Use only the dosing cap that comes with the powder to measure your dose accurately.
Storing and Disposing of Your Medication
Store your medication at room temperature in a dry place, avoiding the bathroom. Keep all medications in a safe location, out of the reach of children and pets. Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so. If you have questions about disposing of your medication, consult your pharmacist. You may also want to check if there are drug take-back programs available in your area.
Managing Missed Doses
If you take this medication on a regular basis and miss a dose, take it as soon as you remember. However, if it's close to the time for your next scheduled dose, skip the missed dose and resume your normal dosing schedule. Do not take two doses at the same time or take extra doses. If you take this medication as needed, do not take it more frequently than directed by your doctor.
Lifestyle & Tips
- Increase fluid intake (especially water)
- Increase dietary fiber (fruits, vegetables, whole grains)
- Engage in regular physical activity
- Do not use for more than 7 days unless directed by a doctor.
Available Forms & Alternatives
Dosing & Administration
Adult Dosing
Standard Dose:
17 g (one heaping tablespoon or one packet) of powder dissolved in 4 to 8 ounces of water or other beverage once daily.
Dose Range:
17 - 34 mg
Condition-Specific Dosing:
occasionalConstipation:
17 g once daily. May take 2-4 days to produce a bowel movement.
Pediatric Dosing
Neonatal:
Not established for general OTC use; consult physician for specific medical conditions.
Infant:
Not established for general OTC use; consult physician for specific medical conditions.
Child:
Not established for general OTC use; specific pediatric formulations/doses exist for chronic constipation under medical supervision (e.g., 0.4-0.8 g/kg/day).
Adolescent:
Generally adult dose (17g) for those 17 years and older. For younger adolescents (under 17), consult physician.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment typically needed due to minimal systemic absorption.
Moderate:
No adjustment typically needed due to minimal systemic absorption.
Severe:
No adjustment typically needed due to minimal systemic absorption.
Dialysis:
No adjustment typically needed due to minimal systemic absorption.
Hepatic Impairment:
Mild:
No adjustment typically needed due to minimal systemic absorption.
Moderate:
No adjustment typically needed due to minimal systemic absorption.
Severe:
No adjustment typically needed due to minimal systemic absorption.
Pharmacology
Mechanism of Action
Polyethylene Glycol 3350 is an osmotic laxative. It works by retaining water in the bowel lumen, which softens the stool and increases stool bulk. This increased bulk stimulates peristalsis, promoting bowel movements.
Pharmacokinetics
Absorption:
Bioavailability:
< 0.2%
Tmax:
Not applicable (minimal systemic absorption)
FoodEffect:
None significant
Distribution:
Vd:
Not applicable (remains primarily in GI tract)
ProteinBinding:
Not applicable (minimal systemic absorption)
CnssPenetration:
No
Elimination:
HalfLife:
Not applicable (minimal systemic absorption)
Clearance:
Not applicable (minimal systemic absorption)
ExcretionRoute:
Feces (primarily unchanged)
Unchanged:
> 99%
Pharmacodynamics
OnsetOfAction:
2-4 days (for full effect, though some effect may be seen sooner)
PeakEffect:
Not applicable (gradual effect)
DurationOfAction:
Variable, depends on continued use and individual bowel habits.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe dizziness or fainting
Diarrhea
Rectal bleeding or rectal pain
Other Possible Side Effects
Like all medications, this drug can cause side effects. Although many people do not experience any side effects or only have mild ones, it is essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or do not go away, contact your doctor:
Loose, watery, or more frequent stools
Stomach pain or cramps
Gas
Bloating
* Upset stomach
Reporting Side Effects
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, contact your doctor for medical advice. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe dizziness or fainting
Diarrhea
Rectal bleeding or rectal pain
Other Possible Side Effects
Like all medications, this drug can cause side effects. Although many people do not experience any side effects or only have mild ones, it is essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or do not go away, contact your doctor:
Loose, watery, or more frequent stools
Stomach pain or cramps
Gas
Bloating
* Upset stomach
Reporting Side Effects
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, contact your doctor for medical advice. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe abdominal pain or cramping
- Nausea or vomiting
- Rectal bleeding
- No bowel movement after 7 days of use
- Worsening constipation
- Signs of allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
Certain health conditions, including:
+ Bowel obstruction or blockage
+ Abdominal pain
+ Upset stomach
+ Rectal bleeding
+ Vomiting
+ Changes in bowel habits that last longer than 2 weeks
A diagnosis of irritable bowel syndrome
Kidney disease or any other health problems that may interact with this medication
Additionally, provide your doctor and pharmacist with a comprehensive list of all your medications, including:
Prescription and over-the-counter (OTC) drugs
Natural products
* Vitamins
This will help ensure your safety while taking this medication. Do not start, stop, or adjust the dosage of any medication without first consulting your doctor to confirm that it is safe to do so.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
Certain health conditions, including:
+ Bowel obstruction or blockage
+ Abdominal pain
+ Upset stomach
+ Rectal bleeding
+ Vomiting
+ Changes in bowel habits that last longer than 2 weeks
A diagnosis of irritable bowel syndrome
Kidney disease or any other health problems that may interact with this medication
Additionally, provide your doctor and pharmacist with a comprehensive list of all your medications, including:
Prescription and over-the-counter (OTC) drugs
Natural products
* Vitamins
This will help ensure your safety while taking this medication. Do not start, stop, or adjust the dosage of any medication without first consulting your doctor to confirm that it is safe to do so.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. To avoid potential risks, do not use this drug for more than 1 week without explicit instructions from your doctor. Additionally, refrain from using other laxatives or stool softeners unless your doctor advises you to do so. You may not experience the full effects of this medication immediately, as it may take a few days to become fully effective. If you are pregnant, planning to become pregnant, or are currently breast-feeding, it is crucial to discuss your situation with your doctor. This conversation will help you understand the benefits and risks associated with this medication for both you and your baby, allowing you to make an informed decision.
Overdose Information
Overdose Symptoms:
- Severe diarrhea
- Excessive fluid loss
- Electrolyte imbalances (e.g., low potassium)
- Abdominal cramping
- Nausea
- Vomiting
What to Do:
Discontinue use. Rehydrate with fluids and electrolytes. Seek medical attention. Call 1-800-222-1222 (Poison Control).
Drug Interactions
Monitoring
Baseline Monitoring
Patient history of bowel habits and constipation severity
Rationale: To establish baseline and determine appropriateness of therapy.
Timing: Prior to initiation
Routine Monitoring
Frequency and consistency of bowel movements
Frequency: Daily
Target: Regular, soft, formed stools
Action Threshold: No bowel movement after 7 days of use, severe abdominal pain, persistent diarrhea, or worsening symptoms.
Electrolyte levels (Na, K, Cl, HCO3)
Frequency: Only if prolonged use, high doses, or in patients at risk for electrolyte imbalance (e.g., renal impairment, concomitant diuretic use).
Target: Within normal limits
Action Threshold: Significant deviations from normal range.
Symptom Monitoring
- Abdominal pain
- Bloating
- Nausea
- Diarrhea
- Rectal bleeding
- Signs of dehydration (e.g., dry mouth, decreased urination, dizziness)
Special Patient Groups
Pregnancy
Generally considered safe for use during pregnancy due to minimal systemic absorption. Consult a healthcare provider before use.
Trimester-Specific Risks:
First Trimester:
Low risk
Second Trimester:
Low risk
Third Trimester:
Low risk
Lactation
Considered compatible with breastfeeding due to minimal systemic absorption by the mother and negligible transfer into breast milk.
Infant Risk:
Low risk
Pediatric Use
Not for use in children under 17 years of age unless directed by a doctor. Specific pediatric formulations and dosing regimens exist for chronic constipation under medical supervision.
Geriatric Use
Generally safe for use in elderly patients. No specific dose adjustment needed. Monitor for dehydration and electrolyte imbalances, especially if other conditions or medications predispose to these.
Clinical Information
Clinical Pearls
- It may take 2 to 4 days to produce a bowel movement.
- Ensure adequate fluid intake when using PEG 3350 to prevent dehydration.
- Not intended for immediate relief of acute constipation; consider stimulant laxatives for faster action if appropriate.
- Can be mixed with various beverages (water, juice, soda, coffee, tea) without affecting efficacy.
- Often preferred over stimulant laxatives for chronic constipation due to lower risk of tolerance or dependence.
Alternative Therapies
- Other osmotic laxatives (e.g., lactulose, magnesium hydroxide, magnesium citrate)
- Bulk-forming laxatives (e.g., psyllium, methylcellulose)
- Stool softeners (e.g., docusate sodium)
- Stimulant laxatives (e.g., bisacodyl, senna)
- Lubricant laxatives (e.g., mineral oil)
Cost & Coverage
Average Cost:
Price varies widely by retailer and quantity, typically inexpensive (e.g., $10-30 for a large bottle). per 119gm bottle or similar quantity
Generic Available:
Yes
Insurance Coverage:
Often OTC, may be covered by some insurance plans with a prescription or as a preferred OTC item.
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further evaluation and guidance. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may have additional patient information leaflets, so it is a good idea to consult with your pharmacist for more information. If you have any questions or concerns about this medication, do not hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the medication taken, the amount, and the time it occurred.