Plexion Cleansing Cloths60's
It is used to treat pimples (acne).It is used to treat rosacea.It is used to control seborrheic dermatitis.
Drug Class
Anti-acne agent; Anti-seborrheic agent
Pharmacologic Class
Sulfonamide antibiotic; Keratolytic; Antiseptic
Pregnancy Category
Category C
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Plexion Cleansing Cloths contain two active ingredients, sulfur and sulfacetamide, that work together to treat skin conditions like acne, rosacea, and seborrheic dermatitis. Sulfacetamide helps stop the growth of bacteria on the skin, while sulfur helps to dry out and peel away dead skin cells, unclog pores, and reduce oiliness. The cloths provide a convenient way to apply the medication.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. It is essential to use this medication as directed and follow all instructions carefully.
This medication is for topical use only, which means it should be applied directly to the affected area of your skin. Do not take it by mouth.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning. If the medication accidentally gets on your lips or eyelids, rinse it off with water immediately.
Before and after applying the medication, wash your hands thoroughly.
To apply, wet the affected area with water, then lather the medication well and rinse.
Continue using the medication as instructed, even if your symptoms improve.
Unless directed by your doctor, do not cover the treated area with bandages, dressings, or makeup.
Storage and Disposal
To store this medication properly:
Keep it at room temperature, avoiding freezing.
Ensure the lid is tightly closed after each use.
* Store the medication in a dry place, avoiding bathrooms.
Missed Dose
If you miss a dose, use it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not use two doses at the same time or take extra doses.
To use this medication correctly, follow your doctor's instructions and read all the information provided. It is essential to use this medication as directed and follow all instructions carefully.
This medication is for topical use only, which means it should be applied directly to the affected area of your skin. Do not take it by mouth.
Avoid getting the medication in your mouth, nose, or eyes, as it may cause burning. If the medication accidentally gets on your lips or eyelids, rinse it off with water immediately.
Before and after applying the medication, wash your hands thoroughly.
To apply, wet the affected area with water, then lather the medication well and rinse.
Continue using the medication as instructed, even if your symptoms improve.
Unless directed by your doctor, do not cover the treated area with bandages, dressings, or makeup.
Storage and Disposal
To store this medication properly:
Keep it at room temperature, avoiding freezing.
Ensure the lid is tightly closed after each use.
* Store the medication in a dry place, avoiding bathrooms.
Missed Dose
If you miss a dose, use it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not use two doses at the same time or take extra doses.
Lifestyle & Tips
- Use as directed by your doctor. Do not use more often or for longer than prescribed.
- Avoid contact with eyes, mouth, and other mucous membranes. If contact occurs, rinse thoroughly with water.
- Some patients may experience temporary stinging or burning upon application, especially during the first few days of treatment.
- This product may cause skin dryness or irritation. If severe, contact your doctor.
- Sulfur-containing products can have a distinct odor.
- Protect treated areas from sunlight or artificial UV light (tanning beds) as sulfacetamide can increase sun sensitivity. Use sunscreen and wear protective clothing.
- Avoid using other topical acne medications or harsh skin products unless directed by your doctor, as this may increase irritation.
- Store at room temperature, away from moisture and heat.
Available Forms & Alternatives
Dosing & Administration
Adult Dosing
Standard Dose:
Apply to affected areas once or twice daily, or as directed by physician.
Condition-Specific Dosing:
Acne Vulgaris:
Cleanse affected area with one cloth, gently massaging into the skin. Rinse thoroughly with water and pat dry. Use once or twice daily.
Rosacea:
Cleanse affected area with one cloth, gently massaging into the skin. Rinse thoroughly with water and pat dry. Use once or twice daily.
Seborrheic Dermatitis:
Cleanse affected area with one cloth, gently massaging into the skin. Rinse thoroughly with water and pat dry. Use once or twice daily.
Pediatric Dosing
Neonatal:
Not established
Infant:
Not established
Child:
Use with caution and under medical supervision; generally not recommended for children under 12 years unless specifically prescribed.
Adolescent:
Apply to affected areas once or twice daily, or as directed by physician.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Dialysis:
No specific considerations (minimal systemic absorption)
Hepatic Impairment:
Mild:
No adjustment needed (minimal systemic absorption)
Moderate:
No adjustment needed (minimal systemic absorption)
Severe:
No adjustment needed (minimal systemic absorption)
Pharmacology
Mechanism of Action
Sulfacetamide sodium is a sulfonamide antibiotic that competitively inhibits bacterial dihydropteroate synthase, an enzyme essential for bacterial folic acid synthesis. This leads to bacteriostatic action against susceptible organisms (e.g., Propionibacterium acnes). It also exhibits anti-inflammatory properties. Sulfur acts as a keratolytic agent, promoting the shedding of dead skin cells and unclogging pores. It also possesses antibacterial and antifungal properties, and helps to reduce sebum production.
Pharmacokinetics
Absorption:
Bioavailability:
Minimal systemic absorption (topical)
Tmax:
Not applicable (minimal systemic absorption)
FoodEffect:
Not applicable (topical)
Distribution:
Vd:
Not applicable (minimal systemic absorption)
ProteinBinding:
Not applicable (minimal systemic absorption)
CnssPenetration:
No (minimal systemic absorption)
Elimination:
HalfLife:
Not clinically significant (minimal systemic absorption)
Clearance:
Not clinically significant (minimal systemic absorption)
ExcretionRoute:
Not clinically significant (minimal systemic absorption)
Unchanged:
Not clinically significant (minimal systemic absorption)
Pharmacodynamics
OnsetOfAction:
Gradual, typically weeks for noticeable improvement in skin conditions.
PeakEffect:
Weeks to months of consistent use.
DurationOfAction:
Dependent on continued application.
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following signs or symptoms, contact your doctor immediately or seek medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Skin irritation
Rare but severe effects associated with sulfa drugs, including:
+ Liver problems
+ Blood problems
+ Severe skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis)
+ If you experience any of the following, call your doctor right away:
- Rash
- Red, swollen, blistered, or peeling skin
- Red or irritated eyes
- Sores in your mouth, throat, nose, or eyes
- Fever, chills, or sore throat
- Cough that is new or worsening
- Feeling very tired or weak
- Any bruising or bleeding
- Signs of liver problems, such as:
- Dark urine
- Tiredness
- Decreased appetite
- Upset stomach or stomach pain
- Light-colored stools
- Vomiting
- Yellow skin or eyes
A health problem called lupus has been reported with drugs similar to this one, resulting in one death. If you experience any of the following symptoms, contact your doctor immediately:
+ Rash on your cheeks or other body parts
+ Easy sunburn
+ Muscle or joint pain
+ Chest pain or shortness of breath
+ Swelling in the arms or legs
Other Possible Side Effects
Most people taking this medication do not experience significant side effects, or they may only have mild side effects. However, if you notice any of the following side effects or any other unusual symptoms, contact your doctor for advice:
Dry skin
Itching
This is not an exhaustive list of all possible side effects. If you have concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following signs or symptoms, contact your doctor immediately or seek medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Skin irritation
Rare but severe effects associated with sulfa drugs, including:
+ Liver problems
+ Blood problems
+ Severe skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis)
+ If you experience any of the following, call your doctor right away:
- Rash
- Red, swollen, blistered, or peeling skin
- Red or irritated eyes
- Sores in your mouth, throat, nose, or eyes
- Fever, chills, or sore throat
- Cough that is new or worsening
- Feeling very tired or weak
- Any bruising or bleeding
- Signs of liver problems, such as:
- Dark urine
- Tiredness
- Decreased appetite
- Upset stomach or stomach pain
- Light-colored stools
- Vomiting
- Yellow skin or eyes
A health problem called lupus has been reported with drugs similar to this one, resulting in one death. If you experience any of the following symptoms, contact your doctor immediately:
+ Rash on your cheeks or other body parts
+ Easy sunburn
+ Muscle or joint pain
+ Chest pain or shortness of breath
+ Swelling in the arms or legs
Other Possible Side Effects
Most people taking this medication do not experience significant side effects, or they may only have mild side effects. However, if you notice any of the following side effects or any other unusual symptoms, contact your doctor for advice:
Dry skin
Itching
This is not an exhaustive list of all possible side effects. If you have concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe skin irritation, redness, itching, or burning that does not subside.
- Signs of an allergic reaction: rash, hives, swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
- Unusual skin discoloration (rare, but possible with some sulfur products).
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced.
A known sulfa allergy.
Current use of medications containing silver.
Presence of kidney disease.
This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health issues. Never start, stop, or adjust the dosage of any medication without first consulting your doctor.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced.
A known sulfa allergy.
Current use of medications containing silver.
Presence of kidney disease.
This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health issues. Never start, stop, or adjust the dosage of any medication without first consulting your doctor.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.
When applying this drug, avoid putting it on cuts, scrapes, or damaged skin, as this can exacerbate skin irritation. Additionally, using other skin products concurrently with this medication may increase the risk of irritation. Before using any other drugs or products on your skin, including soaps, consult with your doctor to ensure safe use.
Adhere to your doctor's instructions regarding the duration of use, as using this drug for longer than recommended can worsen your skin condition. Furthermore, using this medication too frequently can also lead to a deterioration of your skin problem.
Be aware that this drug may cause staining on clothing or fabric, so take necessary precautions to protect your clothing and fabrics from potential stains.
In the event of accidental ingestion, this drug can be harmful. If you or someone else swallows this medication, immediately contact a doctor or a poison control center for assistance.
If you are pregnant, planning to become pregnant, or are breast-feeding, it is crucial to discuss the benefits and risks of using this medication with your doctor, as this will help you make an informed decision regarding your treatment and the potential impact on your baby.
When applying this drug, avoid putting it on cuts, scrapes, or damaged skin, as this can exacerbate skin irritation. Additionally, using other skin products concurrently with this medication may increase the risk of irritation. Before using any other drugs or products on your skin, including soaps, consult with your doctor to ensure safe use.
Adhere to your doctor's instructions regarding the duration of use, as using this drug for longer than recommended can worsen your skin condition. Furthermore, using this medication too frequently can also lead to a deterioration of your skin problem.
Be aware that this drug may cause staining on clothing or fabric, so take necessary precautions to protect your clothing and fabrics from potential stains.
In the event of accidental ingestion, this drug can be harmful. If you or someone else swallows this medication, immediately contact a doctor or a poison control center for assistance.
If you are pregnant, planning to become pregnant, or are breast-feeding, it is crucial to discuss the benefits and risks of using this medication with your doctor, as this will help you make an informed decision regarding your treatment and the potential impact on your baby.
Overdose Information
Overdose Symptoms:
- Excessive skin irritation, redness, peeling, or dryness if applied too frequently or in excessive amounts.
- Systemic effects are unlikely with topical overdose due to minimal absorption, but if ingested, symptoms could include nausea, vomiting, abdominal pain, and potentially more severe sulfonamide-related effects (e.g., blood dyscrasias, crystalluria) if a large amount is absorbed.
What to Do:
For topical overdose, discontinue use and wash the area thoroughly. Apply a soothing moisturizer. For accidental ingestion, seek immediate medical attention or call a Poison Control Center (1-800-222-1222).
Drug Interactions
Moderate Interactions
- PABA-containing sunscreens (may inhibit sulfacetamide activity)
Monitoring
Baseline Monitoring
Skin condition assessment (e.g., lesion count, erythema, scaling)
Rationale: To establish baseline severity of acne, rosacea, or seborrheic dermatitis.
Timing: Prior to initiation of therapy.
Routine Monitoring
Clinical assessment of skin response and tolerability
Frequency: Periodically, as determined by physician (e.g., every 4-8 weeks initially, then as needed)
Target: Reduction in lesions, erythema, scaling; absence of excessive dryness or irritation.
Action Threshold: Lack of improvement after 6-8 weeks, worsening condition, or significant adverse skin reactions (e.g., severe irritation, allergic reaction) warrant re-evaluation.
Symptom Monitoring
- Skin irritation (redness, itching, burning, stinging)
- Dryness or peeling of skin
- Allergic reactions (rash, hives, swelling)
- Worsening of skin condition
- Unusual discoloration of skin or hair (rare)
Special Patient Groups
Pregnancy
Category C. Use only if the potential benefit justifies the potential risk to the fetus. While systemic absorption is minimal with topical application, sulfonamides can cross the placenta. There are no adequate and well-controlled studies in pregnant women.
Trimester-Specific Risks:
First Trimester:
Potential for teratogenicity with systemic sulfonamides, though risk with topical is low due to minimal absorption.
Second Trimester:
Generally considered lower risk than first trimester, but still Category C.
Third Trimester:
Avoid use near term due to theoretical risk of kernicterus in the neonate (due to displacement of bilirubin from albumin binding sites by sulfonamides), especially in premature infants or those with hyperbilirubinemia. However, this risk is primarily associated with systemic sulfonamide use.
Lactation
L3 (Moderately Safe). Sulfonamides are excreted in breast milk. While systemic absorption from topical application is minimal, caution is advised. Monitor breastfed infants for diarrhea, candidiasis, or rash. Avoid applying to areas where the infant may ingest the product.
Infant Risk:
Low risk for most healthy, full-term infants due to minimal maternal systemic absorption. Theoretical risk of kernicterus in jaundiced or G6PD deficient infants, but this is primarily with systemic sulfonamide exposure.
Pediatric Use
Safety and effectiveness in pediatric patients under 12 years of age have not been established. Use in children should be under strict medical supervision due to potential for increased systemic absorption through immature skin and higher body surface area to weight ratio.
Geriatric Use
No specific dosage adjustments are typically required for geriatric patients. Use with caution in patients with very sensitive or fragile skin, as they may be more prone to irritation.
Clinical Information
Clinical Pearls
- This product is for external use only. Do not ingest.
- Patients should be advised that improvement may not be seen for several weeks and consistent use is important.
- Warn patients about potential for skin dryness, irritation, and increased sun sensitivity.
- Advise patients to avoid contact with eyes, mouth, and mucous membranes. If accidental contact occurs, rinse thoroughly with water.
- The product may have a sulfurous odor, which is normal.
- Some patients may experience temporary stinging or burning upon initial application.
- This product may bleach fabrics, so caution should be exercised when using around clothing or linens.
Alternative Therapies
- Topical retinoids (e.g., tretinoin, adapalene)
- Topical benzoyl peroxide
- Topical antibiotics (e.g., clindamycin, erythromycin)
- Topical azelaic acid
- Topical metronidazole (for rosacea)
- Oral antibiotics (e.g., doxycycline, minocycline)
- Oral isotretinoin (for severe acne)
Cost & Coverage
Average Cost:
$100 - $200 per 60 cloths
Generic Available:
Yes
Insurance Coverage:
Varies by plan; often Tier 2 or 3 for brand, Tier 1 for generic.
General Drug Facts
If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.