Nitroglycerin 0.6mg Sub Tabs 100

Nitroglycerin is an organic nitrate that acts as a vasodilator. It is converted to nitric oxide (NO) in vascular smooth muscle cells, which then activates guanylate cyclase, leading to an increase in cyclic guanosine monophosphate (cGMP). Increased cGMP causes dephosphorylation of myosin light chains, resulting in relaxation of vascular smooth muscle. This leads to systemic vasodilation, primarily affecting venous capacitance vessels (reducing preload) and, to a lesser extent, arterial vessels (reducing afterload). It also dilates coronary arteries, improving myocardial oxygen supply.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe dizziness or fainting
Abnormal heartbeat (fast, slow, or irregular)
Flushing
Blurred vision
Dry mouth
Excessive sweating
Pale skin
Severe nausea or vomiting
Restlessness
Feeling extremely tired or weak

Other Possible Side Effects

Like all medications, this drug can cause side effects. Although many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or persist, contact your doctor:

Dizziness or headache
Mouth tingling
Burning sensation

This list is not exhaustive, and you may experience other side effects not mentioned here. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced.
Certain health conditions, including:
+ Anemia
+ Increased pressure in the head, which may be caused by bleeding in the brain or a head injury
+ Recent heart attack
+ Heart problems
+ Low blood volume
If you are currently taking any of the following medications:
+ Avanafil
+ Riociguat
+ Sildenafil
+ Tadalafil
+ Vardenafil
+ Dihydroergotamine
+ Ergonovine
+ Ergotamine
+ Methylergonovine
Note that this is not an exhaustive list of all potential interactions. Therefore, it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health problems with your doctor and pharmacist to ensure safe use.

To guarantee your safety, always verify with your doctor before starting, stopping, or adjusting the dosage of any medication.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

When starting this medication, avoid driving and other activities that require alertness and clear vision until you understand how it affects you. To minimize the risk of dizziness or fainting, stand up slowly after sitting or lying down, and exercise caution when climbing stairs.

Follow your healthcare provider's instructions for monitoring your blood pressure. Additionally, be aware that this medication may interfere with certain laboratory tests, so it is crucial to notify all your healthcare providers and laboratory personnel that you are taking this drug.

Avoid consuming alcohol while on this medication. If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects.

Be aware that taking more of this medication than prescribed or taking it more frequently can lead to decreased effectiveness, a phenomenon known as tolerance. If you find that this medication is no longer working as well as it should, consult your doctor. Do not exceed the recommended dosage.

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential benefits and risks of this medication with your doctor to ensure the best outcome for you and your baby.

• Phosphodiesterase-5 (PDE5) inhibitors (e.g., sildenafil, tadalafil, vardenafil, avanafil) - concurrent use can cause severe hypotension, syncope, or myocardial ischemia.
• Riociguat (soluble guanylate cyclase stimulator) - concurrent use can cause severe hypotension.

• Other vasodilators (e.g., hydralazine, minoxidil) - additive hypotensive effects.
• Antihypertensive agents (e.g., beta-blockers, calcium channel blockers, ACE inhibitors, ARBs, diuretics) - additive hypotensive effects.
• Alcohol - may enhance hypotensive effects and cause orthostatic hypotension.

• Tricyclic antidepressants - may cause orthostatic hypotension.
• Phenothiazines - may cause orthostatic hypotension.
• Ergotamine - nitrates may reduce the therapeutic effect of ergotamine and enhance its toxicity.

• Not available

• Headache (common, often indicates drug activity)
• Dizziness
• Lightheadedness
• Flushing
• Nausea
• Palpitations
• Blurred vision (rare, severe hypotension)

Nitroglycerin is Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

It is not known whether nitroglycerin is excreted in human milk. Caution should be exercised when nitroglycerin is administered to a nursing woman. The decision to discontinue nursing or to discontinue the drug should take into account the importance of the drug to the mother.

Safety and effectiveness in pediatric patients have not been established. Use is generally not recommended.

Elderly patients may be more susceptible to the hypotensive effects of nitroglycerin. Initiate therapy with the lowest effective dose and titrate carefully. Monitor blood pressure closely.

• Patients should be instructed to sit down when taking nitroglycerin to minimize the risk of orthostatic hypotension and syncope.
• A common side effect is headache ('nitrate headache'), which often indicates the drug is working. This can be managed with acetaminophen or ibuprofen.
• Tablets should cause a slight burning or tingling sensation under the tongue; absence of this sensation does not necessarily mean the tablet is ineffective, but it can be an indicator of potency loss.
• Patients should be advised to call 911 or seek emergency medical attention if chest pain is not relieved after 3 doses taken 5 minutes apart.
• Proper storage is crucial: keep in the original amber glass bottle, tightly capped, away from heat, moisture, and light. Do not store in pill organizers or cotton-filled containers, as this can lead to loss of potency.
• Tolerance to the effects of nitroglycerin can develop with continuous or frequent use. A nitrate-free interval (e.g., 8-12 hours overnight) may be necessary to restore sensitivity.

• Isosorbide dinitrate (oral, sublingual)
• Isosorbide mononitrate (oral)
• Beta-blockers (for chronic angina prophylaxis)
• Calcium channel blockers (for chronic angina prophylaxis)
• Ranolazine (for chronic angina prophylaxis)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may have additional patient information leaflets, so it is a good idea to consult with your pharmacist. If you have any questions or concerns about this medication, do not hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide detailed information about the medication taken, the amount, and the time it occurred.