Motrin 600mg Tablets

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that exerts its analgesic, anti-inflammatory, and antipyretic effects primarily through the reversible inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. This inhibition leads to a reduction in the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Signs of bleeding: vomiting or coughing up blood, vomit that resembles coffee grounds, blood in the urine, black, red, or tarry stools, bleeding from the gums, abnormal vaginal bleeding, unexplained bruises or bruises that enlarge, or uncontrollable bleeding.
Signs of kidney problems: inability to urinate, changes in urine output, blood in the urine, or sudden significant weight gain.
Signs of high potassium levels: irregular heartbeat, confusion, weakness, lightheadedness, dizziness, feeling faint, numbness or tingling, or shortness of breath.
Signs of high blood pressure: severe headache or dizziness, fainting, or changes in vision.
Shortness of breath, sudden significant weight gain, or swelling in the arms or legs.
Chest pain or pressure, or rapid heartbeat.
Weakness on one side of the body, difficulty speaking or thinking, balance changes, drooping on one side of the face, or blurred vision.
Extreme fatigue or weakness.
Ringing in the ears.
Severe back pain.
Changes in vision.

Severe Skin Reactions

This medication can cause severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions. These reactions can be life-threatening and may also affect internal organs. Seek immediate medical help if you experience:

Red, swollen, blistered, or peeling skin
Red or irritated eyes
Sores in the mouth, throat, nose, eyes, genitals, or skin
Fever
Chills
Body aches
Shortness of breath
Swollen glands

Other Side Effects

Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. However, if you notice any of the following side effects or any other symptoms that concern you or do not resolve, contact your doctor:

Constipation, diarrhea, stomach pain, upset stomach, or vomiting
Heartburn
Gas
Dizziness

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction and its symptoms.
Allergies to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
A history of asthma triggered by salicylate drugs, such as aspirin, or NSAIDs.
Certain health conditions, including:
+ Gastrointestinal (GI) bleeding
+ Kidney problems
+ Heart failure (a weak heart)
+ Recent heart attack
Current use of other NSAIDs, salicylate drugs like aspirin, or pemetrexed.
Fertility issues or ongoing fertility evaluation, as this medication may affect pregnancy.
* Pregnancy or plans to become pregnant. This medication can harm an unborn baby if taken after 20 weeks of pregnancy. If you are between 20 and 30 weeks pregnant, only take this medication under your doctor's guidance. Do not take this medication if you are more than 30 weeks pregnant.

This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. Verify that it is safe to take this medication with your existing treatments and health status. Never start, stop, or adjust the dosage of any medication without consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

There is a risk of developing high blood pressure while taking this medication. Your doctor will advise you on how often to have your blood pressure checked. Additionally, discuss your alcohol consumption with your doctor before drinking. If you smoke, consult with your doctor about the potential risks. Individuals with asthma should also talk to their doctor, as they may be more sensitive to this medication.

Adhere to the prescribed dosage and do not exceed the recommended amount, as this may increase the risk of severe side effects. Furthermore, do not take this medication for longer than your doctor has instructed.

Be cautious, as this medication may affect your blood's ability to clot, making you more prone to bleeding. To minimize the risk of injury, use a soft toothbrush and an electric razor.

The use of this medication may increase the risk of heart failure, particularly in individuals with pre-existing heart failure. This can lead to a higher chance of heart attack, hospitalization, and death. Discuss these risks with your doctor. Additionally, people who have recently experienced a heart attack may have a higher risk of heart attack and heart-related death when taking this medication. Your doctor can provide more information on this topic.

There is also a risk of developing aseptic meningitis, a severe brain problem, associated with this medication. Seek immediate medical attention if you experience symptoms such as headache, fever, chills, severe nausea or vomiting, stiff neck, rash, sensitivity to light, drowsiness, or confusion.

In rare cases, this medication can cause liver problems, which can be life-threatening. If you notice any signs of liver problems, such as dark urine, fatigue, loss of appetite, stomach pain or nausea, pale stools, vomiting, or yellowing of the skin or eyes, contact your doctor promptly.

If you are 60 years or older, use this medication with caution, as you may be more susceptible to side effects. Women of childbearing age should be aware that this medication may affect ovulation, potentially impacting fertility. However, this effect is reversible when the medication is stopped. Discuss any concerns with your doctor.

If you are breastfeeding, consult with your doctor to discuss the potential risks to your baby.

• Aspirin (high-dose, for antiplatelet effect, due to interference)
• Other NSAIDs (increased risk of GI and renal adverse effects)
• Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)

• Anticoagulants (e.g., Warfarin, Heparin): Increased risk of bleeding.
• Antiplatelet agents (e.g., Clopidogrel, Aspirin low-dose): Increased risk of bleeding.
• Corticosteroids: Increased risk of GI ulceration/bleeding.
• Diuretics (e.g., Furosemide, Hydrochlorothiazide): Reduced diuretic and antihypertensive effect, increased risk of renal impairment.
• ACE Inhibitors/ARBs (e.g., Lisinopril, Valsartan): Reduced antihypertensive effect, increased risk of renal impairment and hyperkalemia.
• Lithium: Increased lithium plasma concentrations and toxicity.
• Methotrexate: Increased methotrexate plasma concentrations and toxicity.
• Cyclosporine: Increased risk of nephrotoxicity.
• Tacrolimus: Increased risk of nephrotoxicity.

• SSRIs/SNRIs: Increased risk of GI bleeding.
• Digoxin: May increase digoxin plasma concentrations.
• Phenytoin: May increase phenytoin plasma concentrations.
• Sulfonylureas: May enhance hypoglycemic effect.
• Aminoglycosides: May increase aminoglycoside levels (via reduced renal clearance).
• Pemetrexed: Increased risk of myelosuppression, renal, and GI toxicity (avoid concomitant use in patients with renal impairment).

• Alcohol: Increased risk of GI irritation/bleeding.
• Ginkgo Biloba: Theoretical increased bleeding risk.

• Signs of gastrointestinal bleeding (black, tarry stools; coffee-ground vomit; severe abdominal pain)
• Signs of cardiovascular events (chest pain, shortness of breath, weakness on one side of the body, slurred speech)
• Signs of renal impairment (decreased urine output, swelling in ankles/feet, unusual fatigue)
• Signs of liver injury (yellowing of skin/eyes, dark urine, persistent nausea/vomiting, unusual fatigue)
• Signs of allergic reaction (rash, itching, swelling of face/throat, difficulty breathing)
• Unusual bruising or bleeding

Ibuprofen should be avoided during pregnancy, especially in the third trimester, due to the risk of premature closure of the fetal ductus arteriosus and potential for renal dysfunction in the fetus. Use in the first and second trimesters should only be considered if the potential benefit justifies the potential risk to the fetus, and at the lowest effective dose for the shortest duration.

Ibuprofen is considered compatible with breastfeeding. It is excreted into breast milk in very small amounts, and adverse effects in breastfed infants are unlikely.

Ibuprofen is widely used in pediatric populations for fever and pain, but the 600mg strength is typically not used in young children. Dosing is weight-based (5-10 mg/kg/dose). Caution is advised in dehydrated children due to increased risk of renal adverse effects. Always use appropriate pediatric formulations (suspension, drops) and dosing guidelines.

Elderly patients are at increased risk for serious adverse effects of NSAIDs, including gastrointestinal bleeding, renal impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal function, blood pressure, and for signs of GI bleeding closely.

• Always advise patients to take ibuprofen with food, milk, or antacids to minimize GI upset.
• Educate patients about the signs and symptoms of GI bleeding and cardiovascular events, and when to seek immediate medical attention.
• Remind patients that ibuprofen is available over-the-counter in lower strengths (e.g., 200mg), and they should not combine prescription strength with OTC products without medical advice.
• For chronic use, consider co-prescribing a proton pump inhibitor (PPI) or H2 blocker for GI protection, especially in high-risk patients.
• Counsel patients on the importance of hydration to help protect kidney function, especially when taking NSAIDs.
• Ibuprofen can interfere with the antiplatelet effect of low-dose aspirin. If both are necessary, ibuprofen should be taken at least 30 minutes after or 8 hours before immediate-release aspirin.

• Acetaminophen (Tylenol - for pain/fever, no anti-inflammatory effect, different side effect profile)
• Other NSAIDs (e.g., Naproxen, Celecoxib, Diclofenac - different half-lives, COX selectivity, and side effect profiles)
• Opioid analgesics (for severe pain, with higher risk of dependence and side effects)
• Topical analgesics (e.g., topical NSAIDs, capsaicin, lidocaine patches - for localized pain)
• Non-pharmacological therapies (e.g., RICE - Rest, Ice, Compression, Elevation; physical therapy, massage, acupuncture, heat/cold therapy)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others or take someone else's medication. This medication is accompanied by a Medication Guide, which provides crucial information for patients. Please read this guide carefully and review it again whenever you receive a refill. If you have any questions or concerns about this medication, consult your doctor, pharmacist, or healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide details about the medication taken, the quantity, and the time it occurred.