Mesalamine 4gm Kit( 7 X 60ml)

Mesalamine (5-aminosalicylic acid) is thought to exert its anti-inflammatory effect locally in the colon. Its exact mechanism is unknown but is believed to involve inhibition of prostaglandin and leukotriene synthesis in the colon, scavenging of free radicals, and inhibition of inflammatory cell migration.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek emergency medical attention:

Signs of an allergic reaction, such as:
+ Rash or hives
+ Itching or red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing or tightness in the chest or throat
+ Difficulty breathing, swallowing, or talking
+ Unusual hoarseness or swelling of the mouth, face, lips, tongue, or throat
Signs of kidney problems, including:
+ Inability to urinate or changes in urine output
+ Blood in the urine or significant weight gain
+ Back pain, abdominal pain, or blood in the urine (which may indicate a kidney stone)
Chest pain or pressure, rapid or irregular heartbeat
Fever, chills, sore throat, unexplained bruising or bleeding, or feeling extremely tired or weak
Rectal bleeding or pain
Symptoms that may resemble ulcerative colitis, such as:
+ New or worsening stomach pain or cramps
+ Bloody stools
+ Fever
+ Headache
+ Itching or rash
+ Red or pink eyes
+ General feeling of illness
Signs of liver problems, which can be rare but potentially life-threatening:
+ Dark urine
+ Fatigue
+ Decreased appetite
+ Nausea or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Signs of heart problems, which can be rare but potentially life-threatening:
+ Shortness of breath
+ Significant weight gain
+ Swelling in the arms or legs
Severe skin reactions, including:
+ Stevens-Johnson syndrome (SJS)
+ Toxic epidermal necrolysis (TEN)
+ Other serious reactions that can affect body organs and be life-threatening
+ Symptoms may include:
- Red, swollen, blistered, or peeling skin
- Red or irritated eyes
- Sores in the mouth, throat, nose, eyes, genitals, or skin
- Fever
- Chills
- Body aches
- Shortness of breath
- Swollen glands

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects, contact your doctor if they bother you or do not resolve:

Constipation
Diarrhea
Stomach pain or upset stomach
Vomiting
Heartburn
Gas
Burping
Nose or throat irritation
Dizziness or headache
Back pain
Cough
* Rectal irritation

This is not an exhaustive list of possible side effects. If you have questions or concerns, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
Existing health conditions, including:
+ Kidney disease or liver disease
+ Stomach or bowel ulcers
+ Narrowing of the stomach valve or other types of stomach blockages
+ Blockages in the urinary tract (consult with your healthcare provider)
Other medications you are taking, including:
+ Prescription and over-the-counter (OTC) drugs
+ Natural products
+ Vitamins
Any health problems you have, as this is not an exhaustive list of potential interactions with this medication.

To ensure your safety, it is crucial to verify that it is safe to take this medication with all your existing medications and health conditions. Never start, stop, or change the dosage of any medication without consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Regular blood tests will be necessary, as directed by your doctor, to monitor your condition. Be sure to discuss any concerns or questions with your doctor.

This medication may interfere with certain laboratory tests, so it is crucial to notify all your healthcare providers and laboratory personnel that you are taking this drug.

To stay hydrated, drink plenty of non-caffeinated fluids, unless your doctor advises you to limit your fluid intake. If you have a sulfite allergy, consult your doctor, as some products may contain sulfites.

While taking this medication, you may notice that your urine turns reddish-brown when it comes into contact with surfaces or water that have been treated with bleach, such as in a toilet. However, if you observe that your urine is reddish-brown before it comes into contact with any surfaces or water, monitor your urine flow and contact your doctor if necessary.

You may be more susceptible to sunburn while taking this medication. To minimize this risk, avoid exposure to the sun, sunlamps, and tanning beds, and use sunscreen and protective clothing and eyewear when going outside.

If you are 65 years or older, use this medication with caution, as you may be more prone to side effects.

Not all formulations of this medication are suitable for children, so it is essential to consult your doctor before giving it to a child. Additionally, do not give this medication to children or teenagers who have or are recovering from flu symptoms, chickenpox, or other viral infections, as this may increase the risk of Reye's syndrome, a condition that can cause severe brain and liver damage.

Be aware that this medication may stain certain surfaces, including fabric, flooring, painted surfaces, marble, granite, vinyl, and enamel.

If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor, as they will need to discuss the potential benefits and risks of this medication to you and your baby.

• Azathioprine
• Mercaptopurine (6-MP)

• Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
• Nephrotoxic agents (e.g., tacrolimus, cyclosporine)

• Worsening of ulcerative colitis symptoms (e.g., increased rectal bleeding, diarrhea, abdominal pain)
• Signs of renal dysfunction (e.g., decreased urine output, swelling in ankles/feet)
• Signs of liver dysfunction (e.g., yellowing of skin/eyes, dark urine, persistent nausea/vomiting, abdominal pain)
• Signs of hypersensitivity reaction (e.g., rash, fever, difficulty breathing, chest pain)
• Signs of acute intolerance syndrome (e.g., cramping, acute abdominal pain, bloody diarrhea, fever, headache, rash)
• Signs of blood dyscrasias (e.g., unexplained bruising, bleeding, persistent sore throat, fever)

Generally considered safe for use during pregnancy. Studies in pregnant women have not shown an increased risk of fetal abnormalities. However, use only if clearly needed and potential benefits outweigh risks.

Mesalamine and its metabolite are excreted in breast milk in small amounts. Generally considered compatible with breastfeeding, but monitor breastfed infant for diarrhea.

Safety and efficacy have not been established in pediatric patients. Use in children is off-label and typically reserved for specific cases under specialist supervision.

Use with caution in elderly patients, as they are more likely to have decreased renal function. Monitor renal function closely. Start at the lower end of the dosing range.

• Mesalamine rectal enema is designed for local action in the rectum and sigmoid colon, making it highly effective for proctosigmoiditis with minimal systemic side effects.
• Instruct patients to administer the enema at bedtime and try to retain it overnight for optimal efficacy.
• Patients should be advised that the enema may stain clothing or bedding.
• Monitor renal function, especially in patients with pre-existing kidney disease or those on concomitant nephrotoxic medications.
• Acute intolerance syndrome (cramping, abdominal pain, bloody diarrhea, fever, headache, rash) is a rare but important adverse effect; if suspected, discontinue therapy immediately.

• Mesalamine suppositories (for proctitis)
• Oral mesalamine formulations (e.g., tablets, capsules)
• Corticosteroid enemas or foams (e.g., hydrocortisone, budesonide)
• Immunomodulators (e.g., azathioprine, mercaptopurine) for more severe or extensive disease
• Biologic agents (e.g., infliximab, adalimumab) for moderate to severe disease

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it occurred.