Lodine 300mg Capsules

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. Its mechanism of action, like that of other NSAIDs, is believed to be due to the inhibition of prostaglandin synthesis, primarily through the inhibition of cyclooxygenase (COX) enzymes. Etodolac is considered a relatively COX-2 selective inhibitor at lower doses, but loses selectivity at higher doses.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Note: In rare cases, allergic reactions can be fatal.
Signs of bleeding, including:
+ Vomiting or coughing up blood
+ Vomit that resembles coffee grounds
+ Blood in the urine
+ Black, red, or tarry stools
+ Bleeding from the gums
+ Abnormal vaginal bleeding
+ Unexplained bruises or bruises that enlarge
+ Uncontrollable bleeding
Signs of kidney problems, such as:
+ Inability to urinate
+ Changes in urine output
+ Blood in the urine
+ Sudden weight gain
Signs of high potassium levels, including:
+ Abnormal heartbeat
+ Confusion
+ Weakness, lightheadedness, or dizziness
+ Feeling faint
+ Numbness or tingling
+ Shortness of breath
Signs of high blood pressure, such as:
+ Severe headache or dizziness
+ Fainting
+ Changes in vision
Shortness of breath, sudden weight gain, or swelling in the arms or legs
Chest pain or pressure, or rapid heartbeat
Weakness on one side of the body, difficulty speaking or thinking, balance problems, drooping on one side of the face, or blurred vision
Ringing in the ears
Flu-like symptoms
Liver problems, which can be fatal. If you experience any of the following symptoms, contact your doctor immediately:
+ Dark urine
+ Fatigue
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions, which can be fatal. Seek medical help right away if you notice:
+ Red, swollen, blistered, or peeling skin
+ Red or irritated eyes
+ Sores in your mouth, throat, nose, eyes, genitals, or skin
+ Fever
+ Chills
+ Body aches
+ Shortness of breath
+ Swollen glands

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you notice any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:

Constipation
Diarrhea
Stomach pain
Upset stomach
Vomiting
Heartburn
Gas
Dizziness
Fatigue
Weakness
* Headache

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction and its symptoms.
Allergies to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
If you have experienced nasal polyps, swelling of the mouth, face, lips, tongue, or throat, unusual hoarseness, or breathing difficulties after taking aspirin or NSAIDs.
Certain health conditions, including:
+ Gastrointestinal (GI) bleeding or kidney problems.
+ Heart failure (weak heart) or a recent heart attack.
Concurrent use of other NSAIDs, salicylate drugs like aspirin, or pemetrexed.
Use of phenylbutazone.
Fertility issues or ongoing fertility evaluation.
Pregnancy, planned pregnancy, or pregnancy confirmation during treatment. This medication may harm an unborn baby if taken after 20 weeks of gestation. If you are between 20 and 30 weeks pregnant, only take this medication under your doctor's guidance. Do not take this medication if you are more than 30 weeks pregnant.

This list is not exhaustive, and it is crucial to discuss all your medications (prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. Verify that it is safe to take this medication with your existing treatments and health status. Never start, stop, or modify the dosage of any medication without consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

This medication may interfere with certain laboratory tests, so it is crucial to notify all your healthcare providers and laboratory personnel that you are taking this drug. Additionally, be aware that drugs like this one can cause high blood pressure. Follow your doctor's instructions for monitoring your blood pressure.

Before consuming alcohol, discuss the potential risks with your doctor. If you smoke, talk to your doctor about the potential interactions between smoking and this medication. It is vital to adhere to the prescribed dosage and not exceed the recommended amount, as taking more than directed may increase the risk of severe side effects. Do not take this medication for longer than prescribed by your doctor.

If you have asthma, consult with your doctor, as you may be more sensitive to this medication. Be cautious and avoid injuries, as this drug can increase the risk of bleeding. To minimize this risk, use a soft toothbrush and an electric razor.

The use of drugs like this one can increase the risk of heart failure. If you already have heart failure, the risk of heart attack, hospitalization for heart failure, and death may be higher. Discuss these risks with your doctor. Furthermore, people taking drugs like this one after a recent heart attack may have a higher risk of heart attack and heart-related death. In fact, studies have shown that individuals taking these medications after a first heart attack were more likely to die within a year compared to those not taking these medications. Talk to your doctor about these risks.

If you are taking aspirin to prevent a heart attack, consult with your doctor about potential interactions. Older adults (65 years or older) should use this medication with caution, as they may be more susceptible to side effects.

Nonsteroidal anti-inflammatory drugs (NSAIDs) like this one may affect ovulation, which can impact fertility. However, this effect is reversible when the medication is stopped. Discuss any concerns about fertility with your doctor. If you are breastfeeding, inform your doctor, as you will need to discuss the potential risks to your baby.

• Aspirin (high dose, due to increased GI risk)
• Other NSAIDs (due to increased GI risk)

• Anticoagulants (e.g., Warfarin): Increased risk of bleeding.
• Antiplatelet agents (e.g., Clopidogrel, Aspirin low dose): Increased risk of GI bleeding.
• Corticosteroids: Increased risk of GI ulceration/bleeding.
• Diuretics (e.g., Furosemide, Thiazides): Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
• ACE inhibitors/ARBs: Reduced antihypertensive effect, increased risk of renal impairment.
• Lithium: Increased lithium plasma concentrations and toxicity.
• Methotrexate: Increased methotrexate plasma concentrations and toxicity.
• SSRIs/SNRIs: Increased risk of GI bleeding.
• Cyclosporine/Tacrolimus: Increased risk of nephrotoxicity.

• Beta-blockers: Reduced antihypertensive effect.
• Digoxin: Possible increased digoxin levels.
• Phenytoin: Possible increased phenytoin levels.
• Cholestyramine: May reduce etodolac absorption.
• Pemetrexed: Increased risk of myelosuppression, renal, and GI toxicity (avoid concomitant use in patients with creatinine clearance <80 mL/min).

• Not available

• Signs of gastrointestinal bleeding (e.g., black, tarry stools; coffee-ground vomit; severe abdominal pain)
• Signs of cardiovascular events (e.g., chest pain, shortness of breath, weakness on one side of the body, slurred speech)
• Signs of renal dysfunction (e.g., decreased urine output, edema, unusual fatigue)
• Signs of liver injury (e.g., jaundice, dark urine, persistent nausea/vomiting, abdominal pain)
• Skin reactions (e.g., rash, blistering, peeling skin)
• Unexplained weight gain or swelling (edema)
• Vision changes

Use during pregnancy should be avoided, especially during the third trimester, due to potential risks to the fetus.

Etodolac is excreted in breast milk. Use with caution; consider potential risks to the infant versus benefits to the mother. Other NSAIDs with better safety profiles in lactation may be preferred.

Safety and efficacy have not been established in pediatric patients under 18 years of age. Use is generally not recommended.

Elderly patients are at increased risk for serious adverse reactions to NSAIDs, particularly gastrointestinal bleeding and perforation, renal impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration possible. Monitor closely for adverse effects.

• Etodolac is considered to have some COX-2 selectivity, which theoretically might lead to a slightly lower GI risk compared to non-selective NSAIDs, but this benefit is dose-dependent and does not eliminate the risk.
• Always advise patients to take etodolac with food or milk to minimize gastrointestinal upset.
• Educate patients about the signs and symptoms of serious GI and cardiovascular adverse events, and when to seek immediate medical attention.
• For chronic conditions, consider the lowest effective dose and periodically reassess the need for continued therapy.
• Be mindful of concomitant medications, especially those that increase bleeding risk or affect renal function.

• Other NSAIDs (e.g., Ibuprofen, Naproxen, Celecoxib, Diclofenac)
• Acetaminophen (for pain and fever, no anti-inflammatory effect)
• Opioid analgesics (for severe pain, with higher risk of side effects and dependence)
• Topical analgesics (e.g., topical NSAIDs, capsaicin, lidocaine patches)
• Non-pharmacological therapies (e.g., physical therapy, heat/cold therapy, exercise, acupuncture)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others or take someone else's medication. This medication is accompanied by a Medication Guide, which provides crucial information for patients. Please read this guide carefully and review it again whenever your prescription is refilled. If you have any questions or concerns about this medication, consult your doctor, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide details about the medication taken, the quantity, and the time it occurred.