Lidocaine 2% Jelly Gel (uro-Jet)5ml
Overview
What is this medicine?
How to Use This Medicine
To use this medication correctly, follow your doctor's instructions and read all the information provided. It's essential to use this medication only as directed.
Apply this medication to your skin only, as directed by your doctor. Do not take it by mouth.
Avoid getting this medication in your mouth, nose, or eyes, as it may cause burning. If accidental contact occurs, rinse the affected area thoroughly with water.
Wash your hands before and after applying the medication, unless your hand is the treated area. In that case, do not wash your hand after application.
Clean the affected area before applying the medication and make sure it is dry.
Apply the medication to clean, dry, healthy skin.
Unless instructed by your doctor, do not cover the treated area with bandages or dressings.
Storage and Disposal
To store this medication properly:
Keep it at room temperature.
Do not freeze the medication.
Store all medications in a safe place, out of the reach of children and pets.
Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist.
Check with your pharmacist for guidance on the best way to dispose of medications. You may also want to explore drug take-back programs in your area.
Missed Dose Instructions
If you use this medication on a regular basis and miss a dose:
Apply the missed dose as soon as you remember.
If it's close to the time for your next dose, skip the missed dose and resume your regular schedule.
Do not apply two doses at the same time or use extra doses.
* If you use this medication on an as-needed basis, do not use it more frequently than directed by your doctor.
Lifestyle & Tips
- Do not apply to large areas of skin or to broken/irritated skin unless directed by a healthcare professional, as this can increase absorption and risk of side effects.
- Avoid contact with eyes.
- Wash hands thoroughly after handling the jelly.
- Do not use more than the prescribed amount or more frequently than directed.
Available Forms & Alternatives
Available Strengths:
- Lidocaine 4% Top Soln 50ml
- Lidocaine 2% Visc Oral Solution
- Lidocaine 1% Inj, 10ml
- Lidocaine 2% Inj, 2ml
- Lidocaine 4% Injection, 5ml
- Lidocaine 1% Inj, 5ml
- Lidocaine 1% Inj, 20ml
- Lidocaine 2% Inj, 20ml
- Lidocaine 1% Inj, 2ml
- Lidocaine 1% Inj, 50ml
- Lidocaine 2% Inj, 5ml
- Lidocaine 2% Inj, 10ml
- Lidocaine 1% Inj, 30ml
- Lidocaine 2% Inj, 50ml
- Lidocaine 2% Inj, 5ml
- Lidocaine 10mg/ml Inj, 5ml
- Lidocaine 3% Cream 28.35gm
- Lidocaine 3% Cream 85gm
- Lidocaine 2% Topical Jelly 5ml
- Lidocaine 2% Topical Jelly 10ml
- Lidocaine 2% Topical Jelly 20ml
- Lidocaine 20mg/ml Inj, 5ml
- Lidocaine 2% Jelly Gel (uro-Jet)5ml
- Lidocaine 0.5% Inj, 50ml
- Lidocaine 5% Patch
- Lidocaine 5% Topical Ointment 30gm
- Lidocaine 5% Topical Oint 35.44gm
- Lidocaine 5% Topical Ointment 50gm
- Lidocaine 1.5% Inj, 1 Ampule
- Lidocaine 5% Top/oral Oint 50gm
- Lidocaine 4% Cream 15gm
- Lidocaine 4% Cream 30gm
- Lidocaine 4% Cream 5gm
- Lidocaine 3% Cream 85gm
- Lidocaine Pain Relief 4% Patch
- Lidocaine 5% Top/oral Oint (sprmt)
- Lidocaine 5% Anorectal Cream
- Lidocaine 4% Cream 15gm
- Lidocaine 5% Topical Ointment 30gm
- Lidocaine 5% Anorectal Cream 15gm
- Lidocaine Pain Relief 4% Patch
- Lidocaine 5% Cream 30gm
- Lidocaine 2% Inj 25ml
- Lidocaine 5% Ointment 50gm
- Lidocaine 4% Cream 15gm
- Lidocaine 4% Topical Pain Patch
- Lidocaine 3%/hc 0.5% Cream 28.3gm
- Lidocaine 2% Topical Jelly 30ml
Dosing & Administration
Adult Dosing
Condition-Specific Dosing:
Pediatric Dosing
Dose Adjustments
Renal Impairment:
Hepatic Impairment:
Pharmacology
Mechanism of Action
Pharmacokinetics
Absorption:
Distribution:
Elimination:
Pharmacodynamics
Safety & Warnings
Side Effects
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of acidosis (too much acid in the blood), such as:
+ Confusion
+ Fast breathing
+ Fast heartbeat
+ Irregular heartbeat
+ Severe stomach pain, nausea, or vomiting
+ Excessive sleepiness
+ Shortness of breath
+ Feeling extremely tired or weak
Signs of methemoglobinemia, a rare but potentially life-threatening condition, such as:
+ Blue or gray discoloration of the lips, nails, or skin
+ Irregular heartbeat
+ Seizures
+ Severe dizziness or fainting
+ Severe headache
+ Excessive sleepiness
+ Feeling extremely tired or weak
+ Shortness of breath
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Trouble breathing, slow breathing, or shallow breathing
Severe numbness and tingling
Feeling lightheaded, sleepy, confused, or experiencing blurred vision
Seizures
Changes in vision
Feeling nervous and excitable
Dizziness or fainting
Ringing in the ears
Nausea or vomiting
Feeling hot or cold
Shakiness
Twitching
Slow heartbeat
Chest pain
Other Possible Side Effects
Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild ones. If you notice any of the following side effects or any other unusual symptoms, contact your doctor for advice:
Irritation at the site of application
Swelling
Redness
Changes in skin color
This is not an exhaustive list of possible side effects. If you have questions or concerns, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Feeling lightheaded or dizzy
- Drowsiness or confusion
- Ringing in the ears (tinnitus)
- Blurred vision
- Numbness or tingling around the mouth
- Shaking or tremors
- Muscle twitching
- Slow or irregular heartbeat
- Difficulty breathing
- Seizures
Before Using This Medicine
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
The presence of an infection at the site where the medication will be applied.
Any broken skin or open wounds at the application site.
Swollen skin, numbness, or loss of sensation at the application site, as these conditions may affect the medication's absorption or increase the risk of adverse reactions.
If a large area of skin needs to be treated, as this may require special consideration or dosage adjustments.
Additionally, it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. This includes:
All your current medications, to ensure safe use and potential interactions with this medication.
* Any health problems you have, as they may affect the safety or efficacy of this medication.
Remember, do not start, stop, or change the dose of any medication without first consulting your doctor. It is your responsibility to verify that it is safe to take this medication with all your other medications and health conditions.
Precautions & Cautions
There is a risk of developing a severe blood condition called methemoglobinemia with this type of drug. Certain factors can increase this risk, including:
- Having a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD)
- Pre-existing heart or lung problems
- Taking specific other medications
- Being an infant under 6 months of age
If you have a history of methemoglobinemia, be sure to discuss this with your doctor.
Before using any other medications or skin products, including soaps, consult with your doctor.
Adhere to your doctor's instructions regarding the duration of use for this medication. Do not exceed the recommended treatment period.
While using this medication, avoid scratching or rubbing the treated skin area, as it may be numb. Additionally, protect the area from extreme temperatures.
Unless instructed by your doctor, do not apply this medication to cuts, scrapes, or damaged skin.
To minimize the risk of increased drug absorption, avoid exposure to heat sources such as:
- Sunlamps
- Tanning beds
- Heating pads
- Electric blankets
- Heat lamps
- Saunas
- Hot tubs
- Heated waterbeds
Also, avoid taking long, hot baths or sunbathing, as these can cause your body temperature to rise and lead to excessive drug absorption.
If this medication is accidentally ingested, seek immediate medical attention or contact a poison control center.
When considering the use of this medication in children, it is crucial to consult with your doctor, as different brands may be suitable for different age groups. Children may be at a higher risk for certain side effects, so caution is advised.
If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects.
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential benefits and risks of using this medication with your doctor to make an informed decision.
Overdose Information
Overdose Symptoms:
- Severe dizziness or lightheadedness
- Nausea and vomiting
- Tremors or muscle twitching
- Seizures
- Difficulty breathing
- Slow or irregular heartbeat
- Loss of consciousness
What to Do:
If you suspect an overdose, seek immediate medical attention or call a poison control center (1-800-222-1222). Symptoms of overdose can be serious and life-threatening.
Drug Interactions
Major Interactions
- Antiarrhythmics (Class I, e.g., mexiletine, tocainide): Increased risk of cardiac adverse effects.
- Other local anesthetics: Additive systemic toxicity.
Moderate Interactions
- Beta-blockers (e.g., propranolol, metoprolol): May reduce hepatic blood flow, potentially decreasing lidocaine clearance and increasing systemic levels.
- Cimetidine: May inhibit lidocaine metabolism, increasing systemic levels.
- Phenytoin: May alter lidocaine metabolism.
- Succinylcholine: Prolonged neuromuscular blockade.
Monitoring
Baseline Monitoring
Rationale: To identify hypersensitivity reactions to lidocaine or other amide-type local anesthetics.
Timing: Prior to administration
Rationale: Damaged or inflamed mucosa can increase systemic absorption and risk of toxicity.
Timing: Prior to administration
Routine Monitoring
Frequency: During and immediately after application, especially with higher doses or prolonged exposure.
Target: Absence of symptoms
Action Threshold: Any signs of dizziness, drowsiness, confusion, tinnitus, blurred vision, tremors, muscle twitching, seizures, bradycardia, hypotension, or cardiac arrest require immediate intervention.
Frequency: As needed
Target: Adequate local anesthesia
Action Threshold: Inadequate anesthesia may indicate need for re-application (within max dose limits) or alternative methods.
Symptom Monitoring
- Lightheadedness
- Dizziness
- Drowsiness
- Confusion
- Tinnitus
- Blurred vision
- Numbness or tingling around the mouth
- Tremors
- Muscle twitching
- Seizures
- Bradycardia
- Hypotension
- Cardiac arrest (severe toxicity)
Special Patient Groups
Pregnancy
Lidocaine is considered Category B for pregnancy. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy should only be considered if the potential benefit justifies the potential risk to the fetus. Systemic absorption from topical use is generally low.
Trimester-Specific Risks:
Lactation
Lidocaine is excreted into breast milk in small amounts. However, due to its short half-life and low oral bioavailability in the infant, adverse effects on the breastfed infant are unlikely with typical topical use. Considered L2 (likely compatible).
Pediatric Use
Use with extreme caution in pediatric patients, especially infants and young children, as they may be more susceptible to systemic toxicity due to higher absorption rates relative to body weight and immature metabolic pathways. Dosing must be carefully calculated based on weight (not to exceed 4.5 mg/kg).
Geriatric Use
Geriatric patients may be more susceptible to systemic toxicity due to decreased hepatic function, reduced renal clearance of metabolites, and potential for underlying cardiovascular disease. Use the lowest effective dose and monitor closely for adverse effects.
Clinical Information
Clinical Pearls
- Ensure the patient is positioned correctly for optimal jelly instillation and retention in the urethra.
- Allow adequate time (5-10 minutes) for the anesthetic effect to develop before proceeding with the procedure.
- Warn patients about the temporary numbness and potential for urinary retention post-procedure due to the anesthetic effect.
- Always adhere to maximum dose limits to prevent systemic toxicity, especially when applying to inflamed or traumatized mucous membranes.
- Keep out of reach of children; accidental ingestion can be dangerous.
Alternative Therapies
- Other topical local anesthetics (e.g., benzocaine, prilocaine)
- Injectable local anesthetics (for deeper anesthesia)
- Systemic analgesics (for pain management not requiring local anesthesia)