Klayesta Top Pwdr 100,000 30gm
It is used to treat fungal infections of the skin.
Drug Class
Antifungal
Pharmacologic Class
Polyene Antifungal
Pregnancy Category
C
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Nystatin topical powder is an antifungal medicine used to treat skin infections caused by yeast, such as diaper rash or jock itch. It works by stopping the growth of the yeast.
How to Use This Medicine
Proper Use of This Medication
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
This medication is for external use only and should not be taken by mouth. Apply it directly to the affected skin area, avoiding the mouth, nose, and eyes, as it may cause irritation.
Before applying the medication, wash your hands thoroughly. Clean the affected area and dry it well before use. Sprinkle the powder evenly over the affected skin. If you are using this medication to treat athlete's foot, you can also sprinkle it in your shoes and socks.
Storage and Disposal
Store the medication at room temperature, away from heat sources, and keep the lid tightly closed. Do not freeze the medication.
Missed Dose
If you miss a dose, apply it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule. Do not apply two doses at the same time or use extra doses to make up for a missed dose.
To use this medication correctly, follow your doctor's instructions and read all the information provided. Continue using the medication as directed, even if your symptoms improve.
Application Instructions
This medication is for external use only and should not be taken by mouth. Apply it directly to the affected skin area, avoiding the mouth, nose, and eyes, as it may cause irritation.
Before applying the medication, wash your hands thoroughly. Clean the affected area and dry it well before use. Sprinkle the powder evenly over the affected skin. If you are using this medication to treat athlete's foot, you can also sprinkle it in your shoes and socks.
Storage and Disposal
Store the medication at room temperature, away from heat sources, and keep the lid tightly closed. Do not freeze the medication.
Missed Dose
If you miss a dose, apply it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular application schedule. Do not apply two doses at the same time or use extra doses to make up for a missed dose.
Lifestyle & Tips
- Keep the affected skin area clean and dry.
- Avoid tight-fitting clothing that can trap moisture.
- Change diapers frequently for infants.
- Ensure good hygiene practices.
Available Forms & Alternatives
Available Strengths:
Dosing & Administration
Adult Dosing
Standard Dose:
Apply to affected areas 2 to 3 times daily
Condition-Specific Dosing:
cutaneous_candidiasis:
Apply a sufficient amount to cover the affected area 2 to 3 times daily until healing is complete.
Pediatric Dosing
Neonatal:
Apply to affected areas 2 to 3 times daily
Infant:
Apply to affected areas 2 to 3 times daily
Child:
Apply to affected areas 2 to 3 times daily
Adolescent:
Apply to affected areas 2 to 3 times daily
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed (negligible systemic absorption)
Moderate:
No adjustment needed (negligible systemic absorption)
Severe:
No adjustment needed (negligible systemic absorption)
Dialysis:
No specific considerations (negligible systemic absorption)
Hepatic Impairment:
Mild:
No adjustment needed (negligible systemic absorption)
Moderate:
No adjustment needed (negligible systemic absorption)
Severe:
No adjustment needed (negligible systemic absorption)
Pharmacology
Mechanism of Action
Nystatin is a polyene antifungal antibiotic that binds to sterols (primarily ergosterol) in the fungal cell membrane, leading to a change in membrane permeability. This allows for leakage of intracellular components, ultimately causing cell death.
Pharmacokinetics
Absorption:
Bioavailability:
Negligible (systemic from topical application)
Tmax:
Not applicable (local action)
FoodEffect:
Not applicable (topical)
Distribution:
Vd:
Not applicable (local action)
ProteinBinding:
Not applicable (local action)
CnssPenetration:
No (negligible systemic absorption)
Elimination:
HalfLife:
Not applicable (not systemically absorbed)
Clearance:
Not applicable (not systemically absorbed)
ExcretionRoute:
Not applicable (not systemically absorbed)
Unchanged:
Not applicable (not systemically absorbed)
Pharmacodynamics
OnsetOfAction:
Within days of treatment initiation
PeakEffect:
Within 1-2 weeks of consistent use
DurationOfAction:
Maintained with continued application
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Irritation at the site where the medication was applied
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, talk to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Although rare, this medication can cause severe and potentially life-threatening side effects. If you experience any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Irritation at the site where the medication was applied
Other Possible Side Effects
Like all medications, this drug can cause side effects. However, many people do not experience any side effects or only have mild ones. If you have side effects that bother you or do not go away, contact your doctor for advice.
Reporting Side Effects
This list does not include all possible side effects. If you have questions or concerns about side effects, talk to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Increased redness or irritation at the application site
- Worsening of the rash
- Development of new symptoms (e.g., blistering, oozing)
- Signs of an allergic reaction (e.g., severe rash, swelling, difficulty breathing - rare with topical)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is crucial to ensure safe use and minimize potential interactions.
* Any existing health problems, as this medication may interact with other medical conditions or drugs.
To guarantee your safety, do not start, stop, or change the dosage of any medication without first consulting your doctor. It is vital to verify that it is safe to take this medication in combination with your other medications and health conditions. Your doctor and pharmacist will work together to ensure that all your medications, including this one, are safe and appropriate for you to take.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This is crucial to ensure safe use and minimize potential interactions.
* Any existing health problems, as this medication may interact with other medical conditions or drugs.
To guarantee your safety, do not start, stop, or change the dosage of any medication without first consulting your doctor. It is vital to verify that it is safe to take this medication in combination with your other medications and health conditions. Your doctor and pharmacist will work together to ensure that all your medications, including this one, are safe and appropriate for you to take.
Precautions & Cautions
It is essential to inform all of your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are pregnant, planning to become pregnant, or are breast-feeding, you must discuss this with your doctor. This conversation will help you understand the potential benefits and risks of taking this drug, both for you and your baby, allowing you to make an informed decision.
Overdose Information
Overdose Symptoms:
- Topical overdose is highly unlikely due to negligible systemic absorption. Excessive application may lead to local irritation.
What to Do:
Discontinue use and wash the area with soap and water. If irritation persists, consult a healthcare provider. For accidental ingestion, contact a poison control center (1-800-222-1222) or seek medical attention, though systemic toxicity from ingestion is also low due to poor absorption.
Drug Interactions
Monitoring
Routine Monitoring
Resolution of symptoms (e.g., rash, itching, redness)
Frequency: Daily observation by patient/caregiver
Target: Complete resolution of fungal infection
Action Threshold: If symptoms worsen or do not improve within 14 days, re-evaluate diagnosis and treatment.
Local skin irritation/adverse reactions
Frequency: Daily observation by patient/caregiver
Target: Absence of irritation
Action Threshold: Discontinue if severe irritation or sensitization occurs.
Symptom Monitoring
- Reduction in redness
- Decrease in itching
- Resolution of rash or lesions
- Absence of burning or irritation
Special Patient Groups
Pregnancy
Nystatin topical is generally considered safe for use during pregnancy due to minimal systemic absorption. Consult a healthcare provider.
Trimester-Specific Risks:
First Trimester:
Low risk due to negligible systemic absorption.
Second Trimester:
Low risk due to negligible systemic absorption.
Third Trimester:
Low risk due to negligible systemic absorption.
Lactation
Nystatin topical is considered safe for use during breastfeeding. It is minimally absorbed systemically, making infant exposure unlikely. Avoid applying directly to the nipple area if breastfeeding.
Infant Risk:
Very low risk (L1)
Pediatric Use
Safe and effective for use in pediatric patients, including neonates and infants, for cutaneous candidiasis. Dosing is similar to adults.
Geriatric Use
No specific dose adjustments or precautions are necessary for geriatric patients. Safety and efficacy are similar to younger adults.
Clinical Information
Clinical Pearls
- Ensure the affected area is clean and dry before applying the powder.
- Apply a thin layer to cover the entire affected area, including skin folds.
- Continue treatment for at least 2 days after symptoms have cleared to prevent recurrence.
- Nystatin is effective only against fungal infections; it is not effective against bacterial or viral infections.
- Avoid contact with eyes and mucous membranes.
- If using for diaper rash, ensure frequent diaper changes and air exposure to the affected area.
Alternative Therapies
- Clotrimazole topical (cream, lotion, solution)
- Miconazole topical (cream, powder, spray)
- Ketoconazole topical (cream, foam, gel)
- Terbinafine topical (cream, gel, spray)
- Econazole topical (cream)
Cost & Coverage
Average Cost:
$15 - $50 per 30gm powder
Generic Available:
Yes
Insurance Coverage:
Tier 1 or Tier 2 (Generic)
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the overdose, including the medication taken, the amount, and the time it occurred.