K-Phos Neutral Tablets

• Aluminum-containing antacids (e.g., aluminum hydroxide): May bind phosphate and prevent absorption.
• Magnesium-containing antacids/laxatives (e.g., magnesium hydroxide): May increase risk of hypermagnesemia and reduce phosphate absorption.
• Calcium-containing antacids/supplements (e.g., calcium carbonate): May bind phosphate and prevent absorption, increasing risk of ectopic calcification.
• Potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene): Increased risk of severe hyperkalemia.
• ACE inhibitors/ARBs: Increased risk of hyperkalemia.
• NSAIDs: May increase risk of hyperkalemia.
• Digitalis glycosides (e.g., digoxin): Hyperkalemia can exacerbate digoxin toxicity.

• Thiazide diuretics: May cause hypercalcemia and hypophosphatemia, potentially counteracting phosphate supplementation.
• Corticosteroids: May increase renal phosphate excretion, potentially requiring higher phosphate doses.
• Bisphosphonates: Concurrent use may alter mineral metabolism; monitor closely.
• Vitamin D analogs: May increase phosphate absorption; monitor for hyperphosphatemia.

• Other potassium-containing medications or supplements: Increased risk of hyperkalemia.
• Sodium-containing medications or supplements: Increased risk of hypernatremia, especially in patients with compromised renal function or heart failure.

• Muscle weakness
• Fatigue
• Confusion
• Irritability
• Numbness or tingling (paresthesias)
• Muscle cramps or spasms
• Tetany
• Seizures
• Cardiac arrhythmias (palpitations, irregular heartbeat)
• Shortness of breath
• Edema (swelling)
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Increased thirst
• Increased urination

Use with caution. While phosphate, potassium, and sodium are essential electrolytes, excessive intake or electrolyte imbalances can be harmful. Administer only if clearly needed and potential benefits outweigh risks. Close monitoring of maternal electrolyte levels is recommended.

Use with caution. Phosphate, potassium, and sodium are naturally present in breast milk. While essential, excessive maternal intake could theoretically alter breast milk composition and lead to infant electrolyte imbalances. Monitor infant for signs of electrolyte disturbance (e.g., irritability, poor feeding, lethargy). Generally considered compatible with breastfeeding when used at therapeutic doses with appropriate monitoring.

Dosing must be carefully individualized based on weight, age, and specific electrolyte needs. Children, especially infants, are more susceptible to electrolyte imbalances (hyperphosphatemia, hyperkalemia, hypernatremia, hypocalcemia) due to their smaller body size and immature renal function. Close monitoring of serum electrolytes and renal function is essential.

Elderly patients are more likely to have impaired renal function, which increases the risk of hyperphosphatemia, hyperkalemia, and hypernatremia. Initiate therapy with lower doses and monitor serum electrolytes and renal function frequently. They may also be on multiple medications that interact with electrolytes.

• Always take K-Phos Neutral with food or immediately after meals to minimize gastrointestinal irritation (nausea, diarrhea).
• Strict adherence to prescribed dosing and monitoring of serum electrolytes (phosphate, calcium, potassium, sodium) and renal function is crucial to prevent serious complications like hyperphosphatemia, hypocalcemia, hyperkalemia, and hypernatremia.
• Patients with pre-existing renal impairment are at significantly higher risk for electrolyte abnormalities and should use this medication with extreme caution or avoid it.
• If used for urinary acidification, regular monitoring of urine pH is necessary to ensure therapeutic efficacy and prevent over-acidification.
• Educate patients to avoid concurrent use of antacids containing aluminum, magnesium, or calcium, as these can bind phosphate and reduce its absorption.

• Potassium Phosphate (e.g., K-Phos Original, K-Phos M.F.) - primarily potassium and phosphate
• Sodium Phosphate (e.g., K-Phos No. 2) - primarily sodium and phosphate
• Oral phosphate supplements (e.g., Fleet Phospho-Soda - generally not recommended for hypophosphatemia due to high sodium/phosphate load and risk of acute phosphate nephropathy)
• Intravenous phosphate (for severe hypophosphatemia)
• Other urinary acidifiers (e.g., Ammonium Chloride, Methionine, Ascorbic Acid - for specific indications)