Ionosol-Mb D5w Inj, 500ml

Ionosol-Mb D5W provides water, dextrose (carbohydrate source), and essential electrolytes (sodium, potassium, magnesium, chloride, phosphate, and a bicarbonate precursor like acetate/lactate) to maintain fluid and electrolyte balance, prevent dehydration, and provide minimal caloric support. Dextrose is metabolized to provide energy and reduce protein catabolism, while electrolytes are crucial for various physiological functions, including nerve impulse transmission, muscle contraction, and maintaining osmotic pressure.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of fluid and electrolyte problems, such as:
+ Mood changes
+ Confusion
+ Muscle pain or weakness
+ Fast or abnormal heartbeat
+ Severe dizziness or passing out
+ Increased thirst
+ Seizures
+ Feeling very tired or weak
+ Decreased appetite
+ Unable to pass urine or change in the amount of urine produced
+ Dry mouth
+ Dry eyes
+ Severe upset stomach or vomiting
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Swelling, warmth, numbness, change of color, or pain in a leg or arm
Chest pain or pressure
Fever
Shortness of breath, significant weight gain, or swelling in the arms or legs

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:

Irritation or swelling at the injection site
* Pain at the injection site

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects. If you have questions or concerns, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
All medications you are currently taking, including prescription and over-the-counter (OTC) drugs, natural products, and vitamins. This information will help your doctor and pharmacist assess potential interactions between this medication and other substances you are taking.
* Any existing health problems, as this medication may interact with certain conditions.

To ensure your safety, it is crucial to verify that it is safe to take this medication with all your current medications and health conditions. Never start, stop, or adjust the dosage of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

If your medication contains potassium, consult your doctor before using any salt substitutes or products that also contain potassium.

For medications containing dextrose, if you have diabetes (high blood sugar), discuss this with your doctor to ensure safe use.

Regular blood tests will be necessary as directed by your doctor. Be sure to follow their instructions and discuss any concerns with them.

When administering this medication to newborns, exercise caution due to a potentially higher risk of side effects in this age group.

If you are pregnant, planning to become pregnant, or are breastfeeding, notify your doctor. They will help you weigh the benefits and risks of this medication for both you and your baby.

• Severe hypernatremia
• Severe hyperkalemia
• Severe hypermagnesemia
• Severe hyperphosphatemia
• Severe fluid overload (e.g., acute pulmonary edema, decompensated heart failure)
• Anuria

• Potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene, eplerenone) - increased risk of hyperkalemia due to potassium content.
• ACE inhibitors/ARBs - increased risk of hyperkalemia due to potassium content.
• Digoxin - electrolyte imbalances (especially hypokalemia, hypercalcemia, hypermagnesemia) can alter digoxin toxicity, though this solution provides maintenance electrolytes, careful monitoring is needed.
• Corticosteroids - may cause sodium and fluid retention, increasing risk of fluid overload.

• Insulin - may require adjustment due to dextrose content, especially in diabetic patients.
• Diuretics (loop or thiazide) - may alter electrolyte balance, requiring careful monitoring and adjustment of fluid/electrolyte infusion.
• Drugs that prolong QT interval - electrolyte imbalances (especially hypokalemia, hypomagnesemia) can exacerbate this, though this solution provides maintenance electrolytes, careful monitoring is needed.

• Not available

• Signs of fluid overload (e.g., peripheral edema, pulmonary crackles, dyspnea, jugular venous distension)
• Signs of hypernatremia (e.g., thirst, lethargy, confusion, seizures)
• Signs of hyponatremia (e.g., headache, nausea, vomiting, confusion, seizures)
• Signs of hyperkalemia (e.g., muscle weakness, paresthesias, cardiac arrhythmias)
• Signs of hypokalemia (e.g., muscle weakness, cramps, fatigue, cardiac arrhythmias)
• Signs of hyperglycemia (e.g., polyuria, polydipsia, fatigue, blurred vision)
• Signs of hypomagnesemia (e.g., muscle cramps, tremors, seizures, arrhythmias)
• Signs of hypermagnesemia (e.g., lethargy, muscle weakness, hypotension, respiratory depression)
• Signs of hypophosphatemia (e.g., muscle weakness, respiratory failure, confusion)
• Signs of hyperphosphatemia (e.g., tetany, calcification of soft tissues)

Generally considered safe for use during pregnancy when clinically indicated for fluid and electrolyte maintenance. Careful monitoring of fluid balance and electrolytes is essential to prevent complications for both mother and fetus.

Generally considered safe for use during lactation. The components (water, dextrose, electrolytes) are natural constituents of the body and breast milk. Infusion is unlikely to cause adverse effects in the breastfed infant.

Pediatric patients, especially neonates and infants, have different fluid and electrolyte requirements and are more susceptible to fluid overload, electrolyte imbalances, and glucose fluctuations. Dosing must be precisely calculated based on weight and age (e.g., Holliday-Segar method), and close monitoring of fluid balance, electrolytes, and glucose is critical.

Elderly patients may be more susceptible to fluid overload, electrolyte imbalances (especially hyponatremia), and renal impairment. Use with caution, initiate at lower rates, and monitor fluid status, electrolytes, and renal function closely.

• Ionosol-Mb D5W is a maintenance fluid, not a resuscitation fluid. It is hypotonic after dextrose metabolism and should not be used for rapid volume expansion in hypovolemic shock.
• Always assess patient's baseline fluid and electrolyte status before initiating therapy.
• Careful monitoring of intake and output, daily weights, and serum electrolytes is crucial to prevent fluid overload or electrolyte imbalances.
• In patients with diabetes or glucose intolerance, blood glucose monitoring is essential due to the dextrose content.
• Avoid rapid infusion, especially in patients with cardiac or renal impairment, to prevent fluid overload and pulmonary edema.
• This solution contains potassium and magnesium; use with extreme caution or avoid in patients with hyperkalemia or hypermagnesemia, or severe renal impairment.
• The 'Mb' in Ionosol-Mb refers to 'maintenance balance', indicating its suitability for ongoing fluid and electrolyte needs rather than acute deficit replacement.

• Oral rehydration solutions (for mild dehydration, if tolerated)
• Other intravenous fluid types (e.g., Normal Saline (0.9% NaCl) for volume expansion, Lactated Ringer's for balanced electrolyte replacement, Dextrose 5% in Water (D5W) for free water and glucose)
• Specific electrolyte supplements (e.g., potassium chloride, magnesium sulfate) for targeted correction of severe deficiencies.

If your symptoms or health problems persist or worsen, it is essential to contact your doctor for further guidance. To ensure safe use, never share your medication with others, and do not take medication prescribed to someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly. Unless instructed to do so by a healthcare professional, avoid flushing medications down the toilet or pouring them down the drain. If you are unsure about the proper disposal method, consult your pharmacist, who can also inform you about potential drug take-back programs in your area. Some medications may come with an additional patient information leaflet, which your pharmacist can provide. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek medical attention. Be prepared to provide information about the medication taken, the amount, and the time of ingestion.