Humulin R U-100 3ml

Insulin regular binds to specific insulin receptors on target cells (e.g., muscle, adipose tissue, liver), facilitating the cellular uptake of glucose, inhibiting hepatic glucose production, and promoting glycogen synthesis. It also promotes protein synthesis and inhibits lipolysis and proteolysis.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Some allergic reactions can be life-threatening, so prompt medical attention is crucial.
Signs of low potassium levels, including:
+ Muscle pain or weakness
+ Muscle cramps
+ An irregular heartbeat
Swelling in the arms or legs
Thick skin, pits, or lumps at the injection site
Low blood sugar, which may cause:
+ Dizziness or fainting
+ Blurred vision
+ Mood changes
+ Slurred speech
+ Headache
+ Feeling sleepy or weak
+ Shaking
+ Fast heartbeat
+ Confusion
+ Hunger
+ Sweating
+ Seizures

If you experience any of these symptoms, call your doctor right away. If you have low blood sugar, follow the instructions you have been given, which may include taking glucose tablets, liquid glucose, or some fruit juices.

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only have mild ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience:

Weight gain
Irritation at the injection site

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you have low blood sugar (hypoglycemia), as this may affect your treatment.

Additionally, this medication may interact with other health conditions or medications. To ensure your safety, it is crucial to provide your doctor and pharmacist with a comprehensive list of:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* Your health problems, including any medical conditions or diseases

Before starting, stopping, or changing the dose of any medication, including this one, consult with your doctor to confirm it is safe to do so. This will help prevent any potential interactions or adverse effects.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Ensure you have the correct insulin product, as it comes in various containers such as vials, cartridges, and pens. Understand how to accurately measure and prepare your dose. If you have any questions or concerns, consult your doctor or pharmacist.

Be aware that this medication can cause low blood sugar (hypoglycemia), which may lead to seizures, loss of consciousness, permanent brain damage, and even death if not treated promptly. Discuss the risks and symptoms of low blood sugar with your doctor.

Additionally, this medication can cause low blood potassium (hypokalemia), which, if left untreated, may result in abnormal heart rhythms, severe breathing difficulties, and potentially death. Consult your doctor if you experience any symptoms.

Until you understand how this medication affects you, avoid driving and other activities that require alertness. Certain diabetes medications, such as pioglitazone or rosiglitazone, may increase the risk of heart failure when used with insulin. If you are taking one of these medications, discuss the potential risks with your doctor.

During times of stress, such as illness, infection, injury, or surgery, your blood sugar levels may be more challenging to control. Changes in physical activity, exercise, or diet can also impact your blood sugar levels.

For your safety, wear a medical alert identification (ID) that indicates you have diabetes. Do not drive if you have experienced low blood sugar, as this can increase your risk of being involved in an accident.

Monitor your blood sugar levels as directed by your doctor. Regular blood tests will also be necessary to assess your condition; follow your doctor's instructions and discuss any concerns with them.

Before consuming alcohol or using products containing alcohol, consult your doctor. Never share your insulin product, including pens, cartridge devices, needles, or syringes, with another person, even if the needle has been changed, as this can transmit infections.

If you are 65 years or older, use this medication with caution, as you may be more susceptible to side effects. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as you will need to discuss the potential benefits and risks to you and your baby.

• Thiazolidinediones (TZDs): Increased risk of fluid retention and heart failure when co-administered with insulin, especially in patients with pre-existing heart failure.
• Beta-blockers: May mask symptoms of hypoglycemia (e.g., tremor, palpitations) and delay recovery from hypoglycemia.

• Corticosteroids, diuretics (thiazide, loop), sympathomimetics (e.g., epinephrine, albuterol), atypical antipsychotics, danazol, diazoxide, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, somatropin, thyroid hormones: May decrease the hypoglycemic effect of insulin (increase blood glucose).
• ACE inhibitors, angiotensin receptor blockers (ARBs), disopyramide, fibrates, fluoxetine, MAO inhibitors, propoxyphene, salicylates (e.g., aspirin), somatostatin analogs (e.g., octreotide), sulfonamide antibiotics: May increase the hypoglycemic effect of insulin (decrease blood glucose).
• Alcohol: May potentiate the hypoglycemic effect of insulin.

• Symptoms of Hypoglycemia: Sweating, tremor, palpitations, anxiety, hunger, dizziness, lightheadedness, confusion, irritability, headache, blurred vision, slurred speech, weakness, seizures, unconsciousness.
• Symptoms of Hyperglycemia: Polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), fatigue, blurred vision, weight loss, nausea, vomiting, abdominal pain (especially in DKA).

Insulin is the preferred treatment for managing diabetes (pre-existing or gestational) during pregnancy. It does not cross the placenta in significant amounts. Close monitoring of blood glucose is essential, and insulin requirements may change throughout pregnancy.

Insulin is compatible with breastfeeding. It is a large protein molecule and is not excreted into breast milk in clinically significant amounts. It is considered safe for the nursing infant.

Insulin regular is safe and effective for use in pediatric patients with diabetes. Dosing is highly individualized based on age, weight, pubertal status, and glycemic control. Close monitoring is crucial to prevent hypoglycemia.

Geriatric patients may be at increased risk of hypoglycemia due to impaired renal/hepatic function, comorbidities, polypharmacy, and reduced counter-regulatory responses. Dosing should be initiated cautiously and titrated slowly with careful monitoring of blood glucose. Education on hypoglycemia recognition is vital.

• Humulin R U-100 is a short-acting insulin. It should be administered 30 minutes before a meal.
• Always check the insulin label carefully to ensure the correct type and concentration of insulin is being used.
• Rotate injection sites (abdomen, thigh, upper arm, buttocks) to prevent lipodystrophy (fat accumulation or atrophy at injection sites).
• Do not mix Humulin R U-100 with long-acting insulins (e.g., insulin glargine, insulin detemir). It can be mixed with NPH insulin (Humulin N) in the same syringe, drawing regular insulin first.
• Store unopened vials/pens in the refrigerator (2°C to 8°C). Once opened, store at room temperature (below 25°C) and use within 28 days.
• Educate patients and caregivers on the signs and symptoms of hypoglycemia and how to treat it promptly.
• Patients should always carry identification indicating they have diabetes and use insulin.

• Rapid-acting insulins (e.g., insulin lispro, insulin aspart, insulin glulisine)
• Intermediate-acting insulins (e.g., NPH insulin)
• Long-acting insulins (e.g., insulin glargine, insulin detemir, insulin degludec)
• Oral antidiabetic agents (e.g., metformin, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists - for Type 2 Diabetes)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the substance taken, the amount, and the time it occurred.