Gleostine 100mg (hundred Mg) Caps

Lomustine is a nitrosourea alkylating agent. It acts by alkylating DNA and RNA, leading to cross-linking of DNA strands and inhibition of DNA synthesis, RNA synthesis, and protein synthesis. It also carbamoylates proteins, which may contribute to its cytotoxic effects. Its highly lipophilic nature allows it to readily cross the blood-brain barrier.

Serious Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of infection, including:
+ Fever
+ Chills
+ Severe sore throat
+ Ear or sinus pain
+ Cough
+ Increased or discolored sputum
+ Painful urination
+ Mouth sores
+ Wounds that won't heal
Signs of bleeding, such as:
+ Vomiting or coughing up blood
+ Coffee ground-like vomit
+ Blood in the urine
+ Black, red, or tarry stools
+ Bleeding gums
+ Abnormal vaginal bleeding
+ Unexplained bruises or bruises that get bigger
+ Uncontrollable bleeding
Signs of liver problems, including:
+ Dark urine
+ Fatigue
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Signs of kidney problems, such as:
+ Inability to urinate
+ Changes in urine output
+ Blood in the urine
+ Sudden weight gain
Signs of lung or breathing problems, including:
+ Shortness of breath or other breathing difficulties
+ Cough
+ Fever
Chest pain
Confusion
Extreme fatigue or weakness
Balance problems
Speech difficulties
Mouth irritation or mouth sores
Changes in vision
Loss of vision

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild ones. If you're bothered by any of the following side effects or if they don't go away, contact your doctor or seek medical attention:

Upset stomach or vomiting
Hair loss

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, talk to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including any symptoms that occurred.
If you are breastfeeding or plan to breastfeed. You should not breastfeed while taking this medication and for 2 weeks after your last dose.

Potential Interactions with Other Medications or Health Conditions

This medication may interact with other medications or worsen certain health conditions. To ensure your safety, it is crucial to:

Inform your doctor and pharmacist about all medications you are taking, including prescription and over-the-counter drugs, natural products, and vitamins.
Discuss any health problems you have, as they may affect the safety or efficacy of this medication.
* Check with your doctor before starting, stopping, or changing the dose of any medication to avoid potential interactions or adverse effects.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Regularly check your lung function as directed by your doctor and discuss any concerns with them.

As this medication may increase your risk of developing infections, it is crucial to practice good hygiene by washing your hands frequently and avoiding close contact with individuals who have infections, colds, or flu.

You may experience an increased risk of bleeding due to this medication. To minimize this risk, be cautious and avoid injuries. Additionally, use a soft toothbrush and an electric razor to reduce the risk of bleeding.

Long-term use of this medication may elevate your risk of developing other types of cancer. If you have any questions or concerns, consult your doctor.

If you experience gastrointestinal side effects such as stomach upset, vomiting, diarrhea, or decreased appetite, discuss them with your doctor, as there may be ways to mitigate these effects.

Before receiving any vaccinations, consult your doctor, as certain vaccines may not be effective or may increase your risk of infection when taken with this medication.

This medication should be used with caution in children, and your doctor should be consulted to discuss the potential risks and benefits.

It is also important to note that this medication may affect fertility, potentially leading to difficulties in becoming pregnant or fathering a child. If you plan to conceive, discuss this with your doctor before initiating treatment.

If you are pregnant or may become pregnant, it is crucial to be aware that this medication may harm the unborn baby. To prevent pregnancy, you and your partner must use effective birth control methods while taking this medication and for a specified period after the last dose. Your doctor will advise you on the duration of birth control use. If you or your partner becomes pregnant, notify your doctor immediately.

• Live vaccines (increased risk of infection)
• Other myelosuppressive agents (additive myelosuppression)
• Phenytoin (decreased phenytoin levels, potential for seizures)
• Cimetidine (may increase myelosuppression)

• Digoxin (decreased digoxin levels)
• Theophylline (decreased theophylline levels)

• Signs of infection (fever, chills, sore throat)
• Unusual bleeding or bruising
• Severe nausea, vomiting, or diarrhea
• Fatigue, weakness
• Shortness of breath, cough, or other respiratory symptoms
• Jaundice, dark urine, or other signs of liver problems
• Signs of kidney problems (changes in urination)

Lomustine is classified as Pregnancy Category D. It can cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant during therapy. If the drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

It is not known whether lomustine is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from lomustine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Breastfeeding is generally contraindicated.

Lomustine has been used in pediatric patients for certain brain tumors and Hodgkin's lymphoma. Dosing is typically weight or body surface area-based. Pediatric patients may be more susceptible to certain toxicities, particularly pulmonary fibrosis. Close monitoring of blood counts and organ function is essential.

Clinical studies of lomustine did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Elderly patients may have reduced renal or hepatic function and may be more susceptible to myelosuppression and other toxicities. Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

• Lomustine causes delayed and prolonged myelosuppression, with nadirs typically occurring 4-6 weeks after a dose. Blood counts must be monitored weekly for at least 6 weeks after each dose.
• Cumulative myelosuppression is common, requiring careful dose adjustments based on nadir counts from the previous cycle.
• Pulmonary toxicity, including fatal pulmonary fibrosis, is a serious and delayed complication. Patients should be monitored for respiratory symptoms.
• Lomustine is highly lipophilic and readily crosses the blood-brain barrier, making it useful for brain tumors.
• Administer on an empty stomach to minimize nausea and vomiting, though antiemetics are often required.
• Capsules should be swallowed whole; do not chew or open.

• Carmustine (another nitrosourea)
• Temozolomide (for brain tumors)
• Procarbazine (part of MOPP/ABVD for Hodgkin's)
• Other alkylating agents (e.g., cyclophosphamide, ifosfamide)
• Radiation therapy (for brain tumors, Hodgkin's lymphoma)
• Other chemotherapy regimens depending on specific cancer type and stage

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication, including the amount taken and the time it happened, to ensure you receive the best possible care.