Fycompa 4mg Tablets

Perampanel is a selective, non-competitive antagonist of the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on postsynaptic neurons. Glutamate is the primary excitatory neurotransmitter in the central nervous system and is implicated in the initiation and propagation of seizures. By blocking AMPA receptors, perampanel reduces neuronal excitability, thereby exerting its anticonvulsant effect.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Confusion
Hallucinations (seeing or hearing things that are not there)
Memory problems or loss
Change in balance
Severe dizziness or fainting
Difficulty walking
Shortness of breath, significant weight gain, or swelling in the arms or legs

A rare but serious condition has been reported in people taking seizure medications like this one. If you experience any of the following symptoms, contact your doctor immediately:

Swollen glands
Fever
Rash
Painful sores in the mouth or around the eyes
Chest pain
Signs of kidney problems, such as:
+ Inability to urinate
+ Changes in urine output
Signs of liver problems, such as:
+ Dark urine
+ Fatigue
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:

Dizziness
Drowsiness
Fatigue
Weakness
Headache
Upset stomach or vomiting
Back pain
Weight gain
Stomach pain
* Bruising

This is not an exhaustive list of possible side effects. If you have questions or concerns, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction you experienced, including the symptoms that occurred.
If you have a history of kidney disease or liver disease, as these conditions may affect how your body processes this medication.

This list is not exhaustive, and it is crucial to discuss all your health concerns with your doctor. To ensure safe treatment, tell your doctor and pharmacist about:

All prescription and over-the-counter (OTC) medications you are taking
Any natural products or vitamins you are using
* All your health problems, as they may interact with this medication

Before starting, stopping, or changing the dose of any medication, including this one, consult with your doctor to confirm it is safe to do so. This will help prevent potential interactions and ensure the best possible treatment outcome.

It is essential to inform all of your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

Before operating a vehicle or engaging in any activity that requires your full attention, wait until you understand how this medication affects you. It is also crucial to discuss the use of alcohol, marijuana, or other forms of cannabis, as well as prescription or over-the-counter (OTC) medications that may cause drowsiness, with your doctor beforehand.

Do not abruptly discontinue this medication without first consulting your doctor, as this may increase your risk of experiencing seizures. If it is necessary to stop taking this medication, your doctor will provide guidance on how to gradually taper off the dosage.

This medication may increase your risk of falling, which can lead to severe consequences such as head injuries and fractures. Older adults are at a higher risk of falls, so it is vital to discuss this with your doctor.

If you are 65 years or older, exercise caution when taking this medication, as you may be more susceptible to side effects.

It is also important to note that birth control pills and other hormone-based birth control products containing levonorgestrel may be less effective in preventing pregnancy. If you are using a birth control product with levonorgestrel, consider using an additional form of birth control, such as a condom, during treatment and for one month after your last dose of this medication. If you have any questions or concerns, consult your doctor.

Additionally, if you are pregnant, plan to become pregnant, or are breastfeeding, you should discuss the potential benefits and risks of this medication with your doctor to ensure the best possible outcome for both you and your baby.

• Strong CYP3A4/5 inducers (e.g., Carbamazepine, Phenytoin, Oxcarbazepine): Significantly decrease perampanel plasma concentrations, requiring higher perampanel doses.
• Rifampin: May significantly decrease perampanel plasma concentrations.

• Oral Contraceptives (Ethinyl Estradiol): Perampanel 12 mg/day may decrease ethinyl estradiol levels, potentially reducing contraceptive efficacy.
• Levonorgestrel: Perampanel 12 mg/day may decrease levonorgestrel levels.
• Other CNS depressants (e.g., Alcohol, Opioids, Benzodiazepines): May enhance CNS depressant effects (drowsiness, dizziness, ataxia).

• Other AEDs (e.g., Valproate, Levetiracetam): Generally no significant pharmacokinetic interaction, but additive CNS effects are possible.

• Aggression
• Hostility
• Irritability
• Anger
• Homicidal ideation or threats
• Suicidal ideation or behavior
• Depression
• Anxiety
• Psychosis
• Dizziness
• Somnolence
• Fatigue
• Ataxia
• Gait disturbance
• Nausea
• Weight gain

Perampanel is classified as Pregnancy Category C. Studies in animals have shown adverse effects on fetal development. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Perampanel is excreted into breast milk. The half-life is long, leading to prolonged exposure in the infant. Due to the potential for serious adverse reactions in breastfed infants (e.g., sedation, irritability, poor feeding), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Approved for adjunctive treatment of partial-onset seizures with or without secondarily generalized seizures in patients 4 years of age and older, and for monotherapy of partial-onset seizures with or without secondarily generalized seizures in patients 4 years of age and older. Dosing is weight-based for younger children. Safety and efficacy in patients younger than 4 years have not been established.

No specific dose adjustment is required based on age alone. However, elderly patients may be more sensitive to the adverse effects (e.g., dizziness, somnolence, gait disturbance) and should be monitored closely.

• Perampanel has a very long half-life (around 105 hours), allowing for once-daily dosing and slow titration. This also means side effects can be prolonged after discontinuation.
• The Black Box Warning for psychiatric and behavioral reactions is significant; patients and caregivers must be thoroughly counselled on these risks and instructed to report any changes immediately.
• Titration should be slow (2 mg increments weekly) to minimize CNS side effects like dizziness and somnolence.
• Patients on oral contraceptives should be advised about potential reduced efficacy, especially at higher perampanel doses (12 mg/day), and consider alternative or additional birth control methods.
• Avoid abrupt discontinuation, as this can increase seizure frequency or severity.

• Levetiracetam (Keppra)
• Lamotrigine (Lamictal)
• Topiramate (Topamax)
• Valproate (Depakote)
• Carbamazepine (Tegretol)
• Oxcarbazepine (Trileptal)
• Lacosamide (Vimpat)
• Cenobamate (Xcopri)

If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others or take someone else's medication. This medication is accompanied by a Medication Guide, which provides crucial information for patients. Please read this guide carefully and review it again whenever you receive a refill of this medication. If you have any questions or concerns about this medication, consult with your doctor, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide details about the medication taken, the amount, and the time it occurred.