Furosemide 10mg/ml Oral Soln 120ml

Furosemide is a loop diuretic that inhibits the Na+-K+-2Cl- cotransporter in the thick ascending limb of the loop of Henle. This inhibition prevents the reabsorption of sodium, potassium, and chloride, leading to increased excretion of water, sodium, chloride, magnesium, and calcium. It also has a direct vasodilatory effect on renal vasculature, increasing renal blood flow.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
Signs of fluid and electrolyte problems: mood changes, confusion, muscle pain or weakness, irregular or rapid heartbeat, severe dizziness or fainting, increased thirst, seizures, extreme fatigue or weakness, decreased appetite, difficulty urinating or changes in urine output, dry mouth, dry eyes, or severe nausea or vomiting.
Signs of liver problems: dark urine, fatigue, decreased appetite, nausea or stomach pain, pale-colored stools, vomiting, or yellowing of the skin or eyes.
Signs of kidney problems: difficulty urinating, changes in urine output, blood in the urine, or sudden weight gain.
Signs of pancreatitis (pancreas problem): severe stomach pain, severe back pain, or severe nausea or vomiting.
Severe dizziness or fainting.
Abnormal burning, numbness, or tingling sensations.
Blurred vision.
Restlessness.

Severe Skin Reactions

This medication can cause severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions. These reactions can be life-threatening and may also affect other organs. Seek immediate medical help if you experience:

Red, swollen, blistered, or peeling skin.
Red or irritated eyes.
Sores in your mouth, throat, nose, eyes, genitals, or skin.
Fever.
Chills.
Body aches.
Shortness of breath.
Swollen glands.

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you notice any of the following side effects or any other symptoms that bother you or do not go away, contact your doctor:

Dizziness or headache.
Constipation, diarrhea, nausea, vomiting, or decreased appetite.
Stomach cramps.

Reporting Side Effects

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction you experienced, including any symptoms.
If you have difficulty urinating or are unable to pass urine.
If you are dehydrated or have electrolyte imbalances.
Certain health conditions, including liver problems or low blood pressure.
* If you are taking any of the following medications: chloral hydrate, ethacrynic acid, or lithium.

This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. They will help you determine if it is safe to take this medication with your existing treatments and health conditions.

Remember, do not start, stop, or change the dose of any medication without consulting your doctor first. This will help prevent potential interactions and ensure your safety while taking this medication.

Important Warnings and Cautions

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

Caution with Daily Activities
Avoid driving and performing tasks that require alertness until you understand how this medication affects you. To minimize the risk of dizziness or fainting, rise slowly from a sitting or lying position. Be cautious when climbing stairs.

Managing Diabetes
If you have diabetes (high blood sugar), closely monitor your blood sugar levels. Notify your doctor if you experience symptoms of high blood sugar, such as confusion, drowsiness, unusual thirst or hunger, frequent urination, flushing, rapid breathing, or fruity-smelling breath.

Dietary Considerations
If you follow a low-salt or salt-free diet, consult your doctor. Additionally, if you have high blood pressure and are taking this medication, discuss with your doctor before using over-the-counter (OTC) products that may increase blood pressure, such as cough or cold medications, diet pills, stimulants, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, and certain natural products or aids.

Monitoring Your Condition
Regularly check your blood pressure as directed by your doctor. Also, have your blood work checked as scheduled by your doctor and discuss the results with them.

Potential Side Effects
High cholesterol and triglyceride levels have been associated with this medication. If you have high cholesterol or triglycerides, consult your doctor. You may require additional potassium; discuss this with your doctor.

Interactions with Other Substances
Before using alcohol, marijuana or other forms of cannabis, or prescription or OTC medications that may cause drowsiness, consult your doctor.

Sun Sensitivity
This medication may increase your risk of sunburn. Take precautions when exposed to the sun, and notify your doctor if you experience easy sunburning while taking this medication.

Other Potential Risks
Be aware of the possibility of gout attacks. If you have lupus, this medication may reactivate or worsen your condition; promptly report any new or worsening symptoms to your doctor.

Hearing and Blood Cell Problems
Hearing problems, such as decreased hearing or hearing loss, have been reported with this medication. These issues may be temporary or permanent. If you experience ringing in the ears, changes in your hearing, or a feeling of fullness in your ears, contact your doctor immediately. Additionally, low blood cell counts have been associated with this medication, which can lead to bleeding problems, infections, or anemia. Seek medical attention if you have signs of infection (fever, chills, sore throat), unexplained bruising or bleeding, or feel extremely tired or weak.

Special Considerations
If you are 65 or older, use this medication with caution, as you may be more susceptible to side effects.

Pregnancy and Breastfeeding
Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You and your doctor will need to discuss the benefits and risks of this medication to you and your baby.

• Aminoglycosides (e.g., gentamicin, tobramycin): Increased risk of ototoxicity.
• Ethacrynic acid: Increased risk of ototoxicity.
• Lithium: Decreased renal clearance of lithium, leading to increased lithium levels and toxicity.
• Chloral hydrate: Transient flushing, sweating, blood pressure elevation, and tachycardia.
• NSAIDs (e.g., ibuprofen, naproxen): May reduce diuretic and antihypertensive effects of furosemide; increased risk of renal toxicity.
• Phenytoin: May reduce diuretic effect of furosemide.
• Sucralfate: May reduce the natriuretic and antihypertensive effects of furosemide.

• ACE inhibitors/ARBs: Increased risk of hypotension and renal dysfunction, especially with initial doses.
• Digoxin: Increased risk of digoxin toxicity due to furosemide-induced hypokalemia.
• Corticosteroids: Increased risk of hypokalemia.
• Amphotericin B: Increased risk of hypokalemia.
• Cisplatin: Increased risk of ototoxicity and nephrotoxicity.
• Metformin: Increased metformin concentrations.
• Cyclosporine: Increased risk of gouty arthritis due to hyperuricemia.

• Antidiabetic agents: May decrease the hypoglycemic effect of antidiabetic agents.
• Muscle relaxants (non-depolarizing): May potentiate the effect of muscle relaxants.

• Dizziness
• Lightheadedness
• Muscle cramps or weakness
• Nausea
• Vomiting
• Excessive thirst
• Dry mouth
• Increased urination
• Fatigue
• Confusion
• Irregular heartbeat
• Hearing changes (tinnitus, hearing loss)

Category C. Use only if the potential benefit justifies the potential risk to the fetus. Furosemide can cross the placenta. There are no adequate and well-controlled studies in pregnant women. Animal studies have shown some adverse effects.

L3 (Moderately Safe). Furosemide is excreted into breast milk and can inhibit lactation by suppressing milk production. Use with caution. Monitor infant for dehydration, electrolyte imbalance, and weight loss.

Dosing is weight-based and individualized. Neonates and infants may be more susceptible to electrolyte imbalances and ototoxicity. Careful monitoring of fluid and electrolyte status is crucial. Oral solution is often preferred for ease of administration.

Elderly patients may be more susceptible to the hypotensive and electrolyte-depleting effects of furosemide. Start with lower doses and titrate carefully. Monitor renal function, electrolytes, and blood pressure closely. Increased risk of falls due to orthostatic hypotension.

• Furosemide is a potent diuretic; careful monitoring of fluid and electrolyte status is essential to prevent dehydration and severe electrolyte imbalances (especially hypokalemia).
• Administer oral doses in the morning to avoid nocturia (nighttime urination). If a second dose is needed, give it in the late afternoon.
• Patients should be advised to report symptoms of electrolyte imbalance (e.g., muscle cramps, weakness, irregular heartbeat) immediately.
• Ototoxicity (hearing loss, tinnitus) is a rare but serious side effect, especially with rapid IV administration, high doses, or in patients with renal impairment or concurrent use of other ototoxic drugs (e.g., aminoglycosides).
• Furosemide can cause hyperglycemia and hyperuricemia; monitor blood glucose and uric acid levels, especially in diabetic or gout-prone patients.
• Oral solution is useful for patients who cannot swallow tablets or for precise pediatric dosing.

• Other loop diuretics (e.g., torsemide, bumetanide)
• Thiazide diuretics (e.g., hydrochlorothiazide, chlorthalidone) for hypertension or mild edema
• Potassium-sparing diuretics (e.g., spironolactone, amiloride) often used in combination with loop diuretics to counteract potassium loss
• Aldosterone antagonists (e.g., spironolactone, eplerenone) for heart failure with reduced ejection fraction or resistant hypertension
• Vasodilators (e.g., nitrates) for acute heart failure management

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more details. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide information about the medication taken, the amount, and the time it happened.