Fluticasone 0.005% Ointment 30gm

Fluticasone propionate is a synthetic trifluorinated corticosteroid that possesses potent anti-inflammatory, antipruritic, and vasoconstrictive properties. It acts by inducing phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Urgent Side Effects: Seek Medical Help Right Away

While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of high blood sugar, including:
+ Confusion
+ Feeling sleepy
+ Unusual thirst or hunger
+ Passing urine more often
+ Flushing
+ Fast breathing
+ Breath that smells like fruit
Signs of a weak adrenal gland, such as:
+ Severe upset stomach or vomiting
+ Severe dizziness or passing out
+ Muscle weakness
+ Feeling very tired
+ Mood changes
+ Decreased appetite
+ Weight loss
Signs of Cushing's syndrome, including:
+ Weight gain in the upper back or belly
+ Moon face
+ Severe headache
+ Slow healing
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Skin changes, including:
+ Pimples
+ Stretch marks
+ Slow healing
+ Hair growth
Skin irritation
Thinning of the skin
Change in eyesight

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people experience no side effects or only mild ones. If you notice any of the following side effects or any other unusual symptoms, contact your doctor or seek medical help:

Burning or stinging

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
If the patient is a child, as this medication is not intended for pediatric use.
Potential interactions with other medications or health conditions. To ensure safe use, disclose all prescription and over-the-counter medications, natural products, and vitamins you are taking to your doctor and pharmacist.
All your health problems, as they may affect the safety of taking this medication.

Remember to consult with your doctor before starting, stopping, or changing the dose of any medication, including this one, to guarantee safe and effective treatment.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before using any other medications or products on your skin, including soaps, consult with your doctor to ensure safe use.

To minimize potential risks, avoid applying this medication to cuts, scrapes, or damaged skin. When applying it to a large area of skin or near open wounds, exercise caution and discuss the application with your doctor.

Adhere to your doctor's prescribed treatment duration, as using this medication for an extended period beyond the recommended timeframe may exacerbate your skin condition. Additionally, using this medication too frequently can worsen your skin problem.

This medication may increase the risk of developing cataracts or glaucoma; therefore, it is crucial to discuss this potential risk with your doctor. If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor to weigh the benefits and risks of using this medication for both you and your baby.

When breastfeeding, take precautions to avoid applying this medication directly to the nipple or the surrounding area to prevent any potential harm to your baby.

• Ritonavir (and other strong CYP3A4 inhibitors)

• Worsening of skin condition
• Signs of skin infection (redness, pus, warmth, pain)
• Severe burning, itching, or irritation at application site
• Skin thinning, easy bruising, stretch marks (striae)
• Unusual fatigue or weakness
• Weight loss
• Swelling in ankles or feet (rare, systemic effect)

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Minimal systemic absorption is expected with topical use, but large amounts or prolonged use should be avoided.

Considered low risk. Minimal systemic absorption of fluticasone propionate is expected, making infant exposure via breast milk unlikely to be clinically significant. Apply to skin areas away from the breast to avoid direct infant ingestion.

Pediatric patients may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic adverse effects, including HPA axis suppression and Cushing's syndrome. Use the least potent effective corticosteroid for the shortest duration possible. Avoid use in infants and young children unless specifically directed by a physician. Monitor for growth retardation if prolonged use.

No specific dose adjustments are required. However, elderly patients may have thinner skin, which could increase the risk of local adverse effects like skin atrophy or purpura. Monitor for skin integrity.

• Fluticasone propionate 0.005% ointment is a medium-potency topical corticosteroid.
• Ointments are generally more potent than creams for the same concentration and are preferred for dry, scaly lesions.
• Educate patients on the 'thin film' application technique to avoid overuse and minimize systemic absorption.
• Warn patients about the potential for skin atrophy, striae, and telangiectasias with prolonged use, especially in intertriginous areas or on the face.
• Consider HPA axis suppression testing (e.g., ACTH stimulation test) if extensive body surface area is treated, especially in children or with occlusive dressings.
• Avoid abrupt discontinuation after prolonged, extensive use to prevent rebound flares of the dermatosis.

• Other topical corticosteroids (e.g., triamcinolone, mometasone, clobetasol, hydrocortisone)
• Topical calcineurin inhibitors (e.g., tacrolimus, pimecrolimus) for steroid-sparing therapy
• Emollients and moisturizers for barrier repair
• Systemic therapies (e.g., oral corticosteroids, immunosuppressants, biologics) for severe, widespread disease

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.