Fluocinonide 0.05% Soln 60ml

Fluocinonide is a high-potency corticosteroid. It exerts its anti-inflammatory, antipruritic, and vasoconstrictive actions by inducing phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek medical attention:

Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat
Signs of high blood sugar: confusion, drowsiness, excessive thirst or hunger, frequent urination, flushing, rapid breathing, or fruity-smelling breath
Signs of a weak adrenal gland: severe nausea or vomiting, severe dizziness or fainting, muscle weakness, extreme fatigue, mood changes, decreased appetite, or weight loss
Signs of Cushing's syndrome: weight gain in the upper back or abdomen, moon face, severe headache, or slow wound healing
Skin changes: acne, stretch marks, slow healing, or excessive hair growth
Skin irritation
Thinning of the skin

Other Possible Side Effects

Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other unusual symptoms that bother you or persist, contact your doctor:

Burning or stinging sensations
Dry skin
Itching

This is not an exhaustive list of potential side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, any of its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
Potential interactions with other medications or health conditions. This drug may interact with other prescription or over-the-counter medications, natural products, or vitamins, which could affect its safety and efficacy.
All medications you are currently taking, including prescription and over-the-counter drugs, natural products, and vitamins. This information will help your doctor and pharmacist assess potential interactions and ensure safe use.
Any existing health problems, as they may impact the safety and effectiveness of this medication.

To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Before using any other medications or skin products, such as soaps, consult with your doctor to ensure safe use.

When applying this medication, avoid putting it on cuts, scrapes, or damaged skin. Exercise caution when applying it to a large area of skin or near open wounds, and discuss this with your doctor.

Do not use this medication for a longer period than prescribed by your doctor. If you are treating a skin area that will be covered by a diaper, avoid using tight-fitting diapers or plastic pants, as this can increase the amount of medication absorbed into the body.

When using this medication in children, it is crucial to exercise caution, as the risk of certain side effects may be higher in this population. In some cases, this medication may affect growth in children and teenagers, and regular growth checks may be necessary. Discuss this with your doctor.

If you are pregnant, plan to become pregnant, or are breastfeeding, inform your doctor, as you will need to discuss the potential benefits and risks of using this medication to both you and your baby.

• Worsening of skin condition
• Signs of skin infection (redness, pus, warmth, pain)
• Skin thinning, bruising, or stretch marks
• Increased hair growth at application site
• Acne-like eruptions
• Changes in vision (e.g., cataracts, glaucoma, if absorbed systemically over long periods)
• Unusual fatigue or weakness (signs of adrenal suppression)

Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal studies have shown corticosteroids to be teratogenic.

Use with caution. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Avoid applying to the breast area to prevent infant ingestion.

Children are more susceptible to systemic toxicity from topical corticosteroids due to a larger skin surface area to body weight ratio and immature skin barrier. Use the least potent corticosteroid for the shortest duration possible. Adrenal suppression, Cushing's syndrome, and intracranial hypertension have been reported. Monitor growth and development.

No specific dosage adjustments are generally needed. However, elderly patients may have thinner skin, which could increase the risk of local side effects like atrophy or purpura. Use with caution and monitor skin integrity.

• Fluocinonide 0.05% solution is a high-potency topical corticosteroid. It should be used for short-term treatment of severe inflammatory dermatoses.
• The solution formulation is often preferred for hairy areas or weeping lesions.
• Avoid prolonged use (typically >2 weeks) to prevent local side effects (skin atrophy, striae, telangiectasias) and systemic absorption.
• Do not use on the face, groin, or axillae unless specifically directed by a dermatologist, as these areas are more prone to adverse effects.
• Occlusive dressings significantly increase systemic absorption and should be avoided unless specifically prescribed and monitored by a physician.
• Patients should be advised to report any signs of local irritation, infection, or systemic side effects.

• Other topical corticosteroids of varying potencies (e.g., clobetasol, betamethasone, triamcinolone, hydrocortisone)
• Calcineurin inhibitors (e.g., tacrolimus, pimecrolimus) for sensitive areas or long-term use
• Emollients and moisturizers for barrier repair
• Systemic therapies (e.g., methotrexate, biologics) for severe, widespread conditions

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication, including the amount taken and the time it happened, to ensure you receive the best possible care.