Doryx 75mg DR Tablets

Doxycycline is a bacteriostatic antibiotic that inhibits bacterial protein synthesis by binding reversibly to the 30S ribosomal subunit, thereby preventing the binding of aminoacyl transfer RNA to the messenger RNA-ribosome complex. It also exhibits anti-inflammatory properties, particularly at sub-antimicrobial doses (e.g., 20 mg twice daily or 40 mg once daily extended-release), by inhibiting matrix metalloproteinases (MMPs) and other inflammatory mediators.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention immediately:

Signs of an allergic reaction: rash, hives, itching, red, swollen, blistered, or peeling skin (with or without fever), wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat
Signs of liver problems: dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, vomiting, or yellow skin or eyes
Signs of pancreatitis (pancreas problem): severe stomach pain, severe back pain, or severe upset stomach or vomiting
Chest pain or pressure, or a rapid heartbeat
Difficulty urinating or changes in urine output
Fever, chills, or sore throat; unexplained bruising or bleeding; or feeling extremely tired or weak
Throat irritation or trouble swallowing
Muscle or joint pain
Rapid breathing or flushing
Severe dizziness or fainting
Changes in skin color
Vaginal itching or discharge
Diarrhea (common with antibiotics), especially if severe, watery, or bloody (may be a sign of C. diff-associated diarrhea, a potentially life-threatening condition)

If you experience any of these symptoms, call your doctor right away. Additionally, be aware that:

C. diff-associated diarrhea (CDAD) may occur during or after antibiotic treatment, which can lead to a potentially life-threatening bowel problem. If you have stomach pain, cramps, or severe diarrhea, contact your doctor immediately.
Raised pressure in the brain has been reported with this medication, which may cause headaches or vision problems (such as blurred vision, double vision, or loss of vision). If you experience any of these symptoms, seek medical attention right away.

Other Possible Side Effects

Most people do not experience severe side effects, but some may occur. If you notice any of the following side effects, contact your doctor if they bother you or do not go away:

Diarrhea, upset stomach, or vomiting
* Decreased appetite

This is not an exhaustive list of possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances. Be sure to describe the symptoms you experienced.
If you are currently taking any of the following medications: Acitretin, Isotretinoin, or a Penicillin.
* If you are breastfeeding or plan to breastfeed, as you may need to avoid breastfeeding while taking this medication.

This list is not exhaustive, and it is crucial to discuss all your medications (including prescription, over-the-counter, natural products, and vitamins) and health conditions with your doctor and pharmacist. They will help determine if it is safe to take this medication with your other medications and health conditions. Never start, stop, or change the dose of any medication without first consulting your doctor.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are on long-term treatment with this drug, your doctor may recommend regular blood tests to monitor your condition.

This medication may interfere with certain laboratory tests, so be sure to notify all your healthcare providers and lab personnel that you are taking this drug. Do not exceed the prescribed duration of treatment, as this may increase the risk of a second infection.

You may be more susceptible to sunburn while taking this medication, so take necessary precautions when exposed to the sun. If you experience unusual sunburn or sensitivity, inform your doctor promptly.

There is a risk of severe skin reactions associated with this medication, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious conditions that can affect internal organs. These reactions can be life-threatening. Seek immediate medical attention if you experience symptoms such as red, swollen, blistered, or peeling skin; red or irritated eyes; sores in your mouth, throat, nose, eyes, genitals, or skin; fever; chills; body aches; shortness of breath; or swollen glands.

If you are using birth control pills or other hormone-based contraception, note that this medication may reduce their effectiveness. Consider using an additional form of birth control, such as condoms, to prevent pregnancy.

In children under 8 years old, this medication may cause permanent tooth discoloration (yellow-gray brown) or other tooth problems. It may also affect bone growth. If you have concerns, discuss them with your doctor. Additionally, if taken during certain stages of pregnancy, this medication may cause tooth discoloration in the unborn baby, which is permanent.

Although this medication is not typically recommended for children under 8 years old, there may be exceptions. Consult with your doctor to determine the best course of treatment.

In some cases, adults have also experienced tooth discoloration, which has been reported to reverse after stopping the medication and undergoing dental cleaning. If you have questions or concerns, discuss them with your doctor.

If you are pregnant or become pregnant while taking this medication, you should contact your doctor immediately, as it may harm the unborn baby.

• Isotretinoin (increased risk of pseudotumor cerebri)
• Acitretin (increased risk of pseudotumor cerebri)

• Antacids containing aluminum, calcium, or magnesium (decreased doxycycline absorption)
• Iron preparations (decreased doxycycline absorption)
• Bismuth subsalicylate (decreased doxycycline absorption)
• Oral retinoids (e.g., tretinoin, adapalene, tazarotene) (increased risk of pseudotumor cerebri)
• Penicillins (tetracyclines may interfere with the bactericidal action of penicillins)
• Warfarin (potentiates anticoagulant effect, monitor INR)
• Live bacterial vaccines (e.g., oral typhoid vaccine) (may reduce vaccine efficacy)

• Barbiturates (e.g., phenobarbital) (decreased doxycycline half-life)
• Carbamazepine (decreased doxycycline half-life)
• Phenytoin (decreased doxycycline half-life)
• Oral contraceptives (may reduce efficacy of oral contraceptives, advise backup method)
• Methotrexate (increased methotrexate toxicity, monitor)

• Dairy products (less significant with delayed-release formulations, but still advise separation by 1-2 hours)

• Nausea
• Vomiting
• Diarrhea
• Photosensitivity (severe sunburn-like reaction)
• Headache (especially severe or persistent)
• Blurred vision
• Diplopia (double vision)
• Dizziness
• Difficulty swallowing
• Esophageal irritation/ulceration (chest pain, heartburn)
• Rash
• Vaginal yeast infection
• Oral thrush

Doxycycline is classified as Pregnancy Category D. It should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. Tetracyclines can cause permanent discoloration of teeth (yellow-gray-brown) and reversible inhibition of bone growth in the fetus.

Doxycycline is excreted into breast milk. While the amount transferred is small and chelation with calcium in milk may reduce absorption by the infant, there is a theoretical risk of tooth discoloration and inhibition of bone growth in the nursing infant. The American Academy of Pediatrics considers tetracyclines to be compatible with breastfeeding with caution. Use with caution, or consider an alternative, especially for long-term use.

Contraindicated in children under 8 years of age due to the risk of permanent tooth discoloration (yellow-gray-brown) and reversible inhibition of bone growth. Use in children 8 years and older should be carefully weighed against these risks.

No specific dose adjustment is generally required for elderly patients. However, elderly patients may be more susceptible to adverse effects such as photosensitivity and gastrointestinal irritation. Monitor for these effects.

• Doryx 75mg DR is specifically formulated for once-daily dosing and is often used for inflammatory lesions of rosacea and acne, leveraging its anti-inflammatory properties at sub-antimicrobial doses.
• Unlike immediate-release doxycycline, Doryx DR's absorption is less affected by food and dairy products, but taking it with a full glass of water and remaining upright for at least 30 minutes is still crucial to prevent esophageal irritation.
• Emphasize strict sun protection due to significant photosensitivity risk.
• Counsel patients on the signs and symptoms of increased intracranial pressure (severe headache, vision changes) and C. difficile-associated diarrhea, which require immediate medical attention.
• Doxycycline is a broad-spectrum antibiotic, but its use for acne/rosacea at lower doses aims to minimize antimicrobial resistance while still providing anti-inflammatory benefits.

• Other tetracyclines (e.g., minocycline, tetracycline)
• Macrolides (e.g., erythromycin, azithromycin) for certain infections or if tetracyclines are contraindicated
• Topical antibiotics (e.g., clindamycin, erythromycin) for acne/rosacea
• Topical retinoids (e.g., tretinoin, adapalene) for acne
• Benzoyl peroxide for acne
• Oral isotretinoin for severe acne
• Metronidazole (topical or oral) for rosacea

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about your medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide details about the medication taken, the amount, and the time it happened.