D5w/nacl 0.9% Inj, 500ml

Dextrose 5% provides a source of calories (170 kcal/L) and free water. It is rapidly metabolized, providing energy and reducing protein catabolism. Sodium Chloride 0.9% (Normal Saline) is an isotonic solution that provides essential electrolytes (sodium and chloride) in concentrations similar to plasma. It expands the extracellular fluid compartment, including the intravascular and interstitial spaces, and helps maintain osmotic pressure and fluid balance. The combination provides both hydration, some caloric support, and electrolyte replacement.

Serious Side Effects: Seek Medical Help Immediately

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical attention right away:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of fluid and electrolyte problems, such as:
+ Mood changes
+ Confusion
+ Muscle pain or weakness
+ Fast or abnormal heartbeat
+ Severe dizziness or passing out
+ Increased thirst
+ Seizures
+ Feeling very tired or weak
+ Decreased appetite
+ Unable to pass urine or change in the amount of urine produced
+ Dry mouth
+ Dry eyes
+ Severe upset stomach or vomiting
Signs of skin infection, such as:
+ Oozing
+ Heat
+ Swelling
+ Redness
+ Pain
Swelling, warmth, numbness, change of color, or pain in a leg or arm
Chest pain or pressure
Fever
Shortness of breath
Sudden weight gain
Swelling in the arms or legs

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild ones. If you notice any of the following side effects or any other unusual symptoms, contact your doctor for advice:

Irritation or swelling at the injection site
* Pain at the injection site

This is not an exhaustive list of all possible side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced as a result of the allergy.
Potential interactions with other medications or health conditions. This drug may interact with other prescription or over-the-counter (OTC) medications, natural products, or vitamins, which could affect its safety and efficacy.
All medications you are currently taking, including prescription and OTC drugs, natural products, and vitamins. This information will help your doctor and pharmacist assess potential interactions and ensure safe use.
Any existing health problems, as they may impact the safety and effectiveness of this medication.

To ensure your safety, do not start, stop, or change the dose of any medication without first consulting your doctor. It is crucial to verify that it is safe to take this medication with all your other medications and health conditions.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication.

If your medication contains potassium, consult your doctor before using a salt substitute or any product that also contains potassium.

If your medication contains dextrose and you have diabetes (high blood sugar), discuss this with your doctor to determine the best course of action.

Regular blood tests are crucial while taking this medication. Follow your doctor's instructions regarding the frequency and timing of these tests, and discuss the results with your doctor.

When administering this medication to a newborn, exercise caution, as the risk of side effects may be increased in this age group.

If you are pregnant, planning to become pregnant, or are breastfeeding, inform your doctor. It is crucial to discuss the potential benefits and risks of this medication to both you and your baby to make an informed decision.

• Not typically contraindicated with specific drugs, but rather in conditions like severe fluid overload, hypernatremia, or uncontrolled hyperglycemia.

• Corticosteroids (e.g., Prednisone, Dexamethasone): Can cause sodium and fluid retention, increasing risk of fluid overload and electrolyte imbalance when co-administered with saline solutions.
• Drugs causing sodium retention (e.g., NSAIDs, some antihypertensives): Increased risk of fluid overload and hypernatremia.
• Insulin: Dextrose can increase blood glucose; insulin requirements may change.
• Diuretics (e.g., Furosemide, Hydrochlorothiazide): Can alter fluid and electrolyte balance, requiring careful monitoring to avoid hypo- or hypernatremia, and hypo- or hyperglycemia.

• Lithium: Sodium intake can affect lithium excretion; monitor lithium levels.
• Drugs affecting glucose metabolism (e.g., Beta-blockers, Thiazide diuretics): May alter glucose response to dextrose.

• None specifically identified as minor drug-drug interactions for the solution itself, interactions are primarily related to fluid and electrolyte balance.

• Signs of fluid overload (e.g., dyspnea, orthopnea, peripheral edema, weight gain, crackles on lung auscultation, jugular venous distention)
• Signs of hypernatremia (e.g., thirst, lethargy, weakness, irritability, seizures, coma)
• Signs of hyperglycemia (e.g., polyuria, polydipsia, fatigue, blurred vision, headache)
• Signs of electrolyte imbalance (e.g., muscle weakness, cramps, confusion, cardiac arrhythmias)

Generally considered safe and often used during pregnancy when clinically indicated for hydration, electrolyte replacement, or as a vehicle for medication. However, careful monitoring of fluid and electrolyte balance is crucial to avoid fluid overload or imbalances that could affect both mother and fetus.

Compatible with breastfeeding. The components (water, dextrose, sodium, chloride) are natural constituents of breast milk and are not expected to cause adverse effects in the infant.

Dosing must be carefully calculated based on weight, age, and clinical status to prevent fluid overload, electrolyte imbalances (especially hyponatremia), and hyperglycemia. Neonates and infants are particularly vulnerable to fluid and electrolyte shifts. Close monitoring of fluid intake/output, weight, serum electrolytes, and blood glucose is essential.

Increased susceptibility to fluid overload, electrolyte disturbances (e.g., hyponatremia, hypernatremia), and hyperglycemia due to age-related changes in renal function, cardiac reserve, and thirst perception. Initiate at lower rates and volumes, and monitor fluid balance, electrolytes, and renal function very closely. Avoid rapid infusions.

• Always assess patient's fluid status, electrolyte levels, and renal function before initiating and throughout IV fluid therapy.
• D5W/0.9% NaCl is isotonic initially but becomes hypotonic as dextrose is metabolized, providing free water. This should be considered in patients at risk for cerebral edema.
• Not a complete nutritional solution; provides minimal calories and no protein, vitamins, or trace elements.
• Risk of fluid overload is significant, especially in patients with heart failure, renal impairment, or liver disease.
• Monitor blood glucose closely, particularly in diabetic patients or those with stress-induced hyperglycemia.
• Use with caution in patients with conditions that cause sodium retention (e.g., heart failure, cirrhosis, renal disease, corticosteroid therapy).

• Lactated Ringer's Solution (LR)
• Plasma-Lyte A
• Other balanced crystalloid solutions
• Oral Rehydration Solutions (ORS) for mild to moderate dehydration if patient can tolerate oral intake
• Total Parenteral Nutrition (TPN) for complete nutritional support

If your symptoms or health problems persist or worsen, it is essential to contact your doctor promptly. To ensure safe use, never share your medication with others, and do not take medication prescribed for someone else. Store all medications in a secure location, out of reach of children and pets, to prevent accidental ingestion. Dispose of unused or expired medications properly. Unless instructed to do so by a healthcare professional, do not flush medications down the toilet or pour them down the drain. If you are unsure about the proper disposal method, consult your pharmacist, who can also inform you about potential drug take-back programs in your area. Some medications may come with an additional patient information leaflet, which your pharmacist can provide. If you have any questions or concerns about your medication, discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately contact your local poison control center or seek medical attention. Be prepared to provide information about the medication taken, the amount, and the time of the incident.