Clindamycin 1% Topical Soln 60ml
Overview
What is this medicine?
How to Use This Medicine
To use this medication correctly, follow your doctor's instructions and read all the information provided. It is essential to use this medication as directed, even if your symptoms improve.
Application Instructions
Apply this medication only to your skin, avoiding the mouth, nose, and eyes, as it may cause burning.
Wash your hands before and after applying the medication.
Clean the affected area before use and dry it thoroughly.
Apply a thin layer of the medication to the affected skin, avoiding open sores or broken skin.
If using pledgets (swabs), remove one from the foil immediately before use, and discard it after a single use. You may use more than one pledget as needed.
Storage and Disposal
Store this medication at room temperature, away from heat sources.
Do not freeze the medication.
Keep it in a dry place, avoiding storage in a bathroom.
Missed Dose Instructions
If you miss a dose, apply it as soon as you remember.
If it is close to the time for your next dose, skip the missed dose and resume your regular schedule.
* Do not apply two doses at the same time or use extra doses to make up for a missed one.
Lifestyle & Tips
- Cleanse skin gently before application.
- Apply a thin layer to the entire affected area, not just individual pimples.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Wash hands thoroughly after application.
- Use sunscreen and protective clothing, as some acne treatments can increase sun sensitivity.
- Be patient; it may take several weeks to see improvement.
Available Forms & Alternatives
Available Strengths:
- Clindamycin 1% Gel 60gm
- Clindamycin 1% Pledgets 60s
- Clindamycin 300mg Capsules
- Clindamycin 1% Lotion 60ml
- Clindamycin 1% Topical Soln 60ml
- Clindamycin 1% Topical Soln 30ml
- Clindamycin 2% Vaginal Cream 40gm
- Clindamycin 150mg Capsules
- Clindamycin 1% Gel 30gm
- Clindamycin 150mg/ml Inj, 60ml
- Clindamycin 1% Foam 100gm
- Clindamycin 1% Foam 50gm
- Clindamycin 150mg Capsules
- Clindamycin 300mg Capsules
- Clindamycin 900mg Inj, 50ml
- Clindamycin 900mg/6ml Inj, 6ml
- Clindamycin Phos/tretinoin Gel 60gm
- Clindamycin 1% Gel (once Daily)75ml
- Clindamycin 75mg Capsules
- Clindamycin Phos/tretinoin Gel 30gm
- Clindamycin Phos/tretinoin Gel 60gm
- Clindamycin 1% Lotion 60ml
- Clindamycin 1% Gel(once Daily)75ml
- Clindamy/d5w 600mg/50ml Inj, 50ml
- Clindamycin Ped 75mg/5ml Sol 100ml
- Clindamycin 300mg/d5w Inj, 50ml
- Clindamy/d5w 900mg/50ml Inj, 50ml
Dosing & Administration
Adult Dosing
Condition-Specific Dosing:
Pediatric Dosing
Dose Adjustments
Renal Impairment:
Hepatic Impairment:
Pharmacology
Mechanism of Action
Pharmacokinetics
Absorption:
Distribution:
Elimination:
Pharmacodynamics
Safety & Warnings
Side Effects
Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek medical help right away:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
A severe form of diarrhea called C. diff-associated diarrhea (CDAD), which can be life-threatening. This may occur while taking the antibiotic or within a few months after stopping it. Watch for:
+ Stomach pain or cramps
+ Very loose or watery stools
+ Bloody stools
Do not attempt to treat diarrhea without consulting your doctor first.
Other Possible Side Effects
Like all medications, this drug can cause side effects. While many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. Contact your doctor or seek medical help if you experience:
Irritation at the site where the medication was applied
Burning
Itching
Dry skin
Redness
Oily skin
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns, don't hesitate to reach out to your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe or persistent diarrhea (even if it occurs weeks after stopping the medication)
- Abdominal pain or cramping
- Bloody or mucus-containing stools
- Severe skin irritation, redness, itching, or peeling that does not improve
- Hives or allergic reaction (rare)
Before Using This Medicine
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the symptoms you experienced.
A history of certain health conditions, including:
+ Crohn's disease
+ Other stomach or bowel problems, such as colitis or enteritis
+ Severe bowel problems that occurred while taking an antibiotic, including severe diarrhea, bowel swelling, or stomach pain
* Current use of products containing erythromycin
This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. They will help you determine if it is safe to take this medication with your existing health conditions and other medications.
Remember, do not start, stop, or change the dose of any medication without first consulting your doctor.
Precautions & Cautions
When using this drug, avoid covering the treated area with bandages, dressings, or makeup unless specifically instructed to do so by your doctor.
Please note that it may take several weeks for the full effects of this medication to become apparent.
Before using any other medications or products on your skin, including soaps, consult with your doctor to ensure safe and effective treatment.
If this drug is accidentally swallowed, it can be harmful. In such an event, immediately contact a doctor or a poison control center for assistance.
If you are pregnant, planning to become pregnant, or are breastfeeding, it is crucial to discuss the potential benefits and risks of this medication with your doctor, as they will help you weigh the advantages and disadvantages for both you and your baby.
For breastfeeding mothers who apply this drug to their breast or nipple, it is recommended to wash the area thoroughly before breastfeeding your child to ensure safety.
Overdose Information
Overdose Symptoms:
- Unlikely with topical application due to minimal systemic absorption.
What to Do:
If accidental ingestion occurs, seek medical attention. For excessive topical application, wash off with water. Call 1-800-222-1222 (Poison Control).
Drug Interactions
Moderate Interactions
- Erythromycin (topical or systemic): May antagonize the antibacterial effect of clindamycin due to competitive binding at the ribosomal 50S subunit. Avoid concomitant use.
Monitoring
Routine Monitoring
Frequency: Regularly during treatment, especially in the first few weeks.
Target: Minimal to no irritation.
Action Threshold: If severe irritation occurs, reduce frequency or discontinue use and consult a healthcare provider.
Frequency: Monthly or as clinically indicated.
Target: Reduction in inflammatory and non-inflammatory lesions.
Action Threshold: If no improvement after 8-12 weeks, re-evaluate treatment plan.
Symptom Monitoring
- Severe or persistent diarrhea (may indicate C. difficile-associated diarrhea, though rare with topical use)
- Abdominal pain or cramping
- Bloody or mucus-containing stools
- Severe skin irritation, blistering, or rash
Special Patient Groups
Pregnancy
Clindamycin topical is considered Category B. Studies in animals have shown no evidence of harm to the fetus, and human data suggest low risk due to minimal systemic absorption. Use if clearly needed.
Trimester-Specific Risks:
Lactation
Considered compatible with breastfeeding (L2). Minimal systemic absorption means very little clindamycin is expected to be excreted into breast milk. Monitor infant for diarrhea or rash.
Pediatric Use
Safe and effective for acne in children 12 years and older. Safety and efficacy in children younger than 12 years have not been established.
Geriatric Use
No specific dosage adjustments are necessary for geriatric patients. Systemic absorption is minimal, so age-related changes in renal or hepatic function are not expected to significantly impact safety or efficacy.
Clinical Information
Clinical Pearls
- Topical clindamycin is often used in combination with benzoyl peroxide to enhance efficacy and reduce the development of bacterial resistance.
- Patients should be advised that improvement in acne may not be seen for several weeks to months.
- Although rare, C. difficile-associated diarrhea (CDAD) has been reported with topical clindamycin. Patients should be instructed to discontinue use and contact their physician if significant diarrhea develops.
- The solution formulation may be drying; patients with sensitive skin may prefer a gel or lotion formulation if available.
- Avoid concurrent use with topical erythromycin due to potential antagonism.
Alternative Therapies
- Topical retinoids (e.g., tretinoin, adapalene, tazarotene)
- Topical benzoyl peroxide
- Topical azelaic acid
- Topical dapsone
- Oral antibiotics (e.g., doxycycline, minocycline, sarecycline) for more severe acne
- Oral isotretinoin (for severe, recalcitrant acne)