Clearlax Powder
It is used to treat constipation.
Drug Class
Laxative
Pharmacologic Class
Osmotic agent
Pregnancy Category
Not assigned (often considered low risk, previously C by some sources due to lack of human studies, but minimal absorption suggests low risk)
FDA Approved
Jan 1970
DEA Schedule
Not Controlled
Overview
What is this medicine?
Polyethylene Glycol 3350 is a laxative that works by drawing water into your intestines. This helps to soften your stool and make it easier to pass, relieving constipation. It usually takes 1 to 3 days to work.
How to Use This Medicine
Taking Your Medication Correctly
To ensure you get the most out of your medication, follow these steps:
1. Always take your medication as directed by your doctor. Read all the information provided with your medication and follow the instructions carefully.
2. To prepare your dose, mix the powder with 1/2 to 1 cup (120 to 240 ml) of a liquid, such as water, juice, soda, coffee, or tea. Stir well to ensure the powder is fully dissolved before drinking. Check the mixture for any clumps before consuming. Do not drink if you notice any clumps.
3. Do not mix your medication with starch-based thickeners.
4. Use only the dosing cap provided with the powder to measure your dose accurately.
Storing and Disposing of Your Medication
To maintain the quality and safety of your medication:
1. Store it at room temperature in a dry place, avoiding bathrooms and areas prone to moisture.
2. Keep all medications in a secure location, out of the reach of children and pets.
3. Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist.
4. Check with your pharmacist for guidance on the best way to dispose of your medication. You may also want to explore drug take-back programs in your area.
What to Do If You Miss a Dose
If you take your medication on a regular schedule:
1. Take a missed dose as soon as you remember.
2. If it's close to the time for your next dose, skip the missed dose and resume your regular schedule.
3. Do not take two doses at the same time or take extra doses.
If you take your medication as needed, follow your doctor's instructions and do not take it more frequently than recommended.
To ensure you get the most out of your medication, follow these steps:
1. Always take your medication as directed by your doctor. Read all the information provided with your medication and follow the instructions carefully.
2. To prepare your dose, mix the powder with 1/2 to 1 cup (120 to 240 ml) of a liquid, such as water, juice, soda, coffee, or tea. Stir well to ensure the powder is fully dissolved before drinking. Check the mixture for any clumps before consuming. Do not drink if you notice any clumps.
3. Do not mix your medication with starch-based thickeners.
4. Use only the dosing cap provided with the powder to measure your dose accurately.
Storing and Disposing of Your Medication
To maintain the quality and safety of your medication:
1. Store it at room temperature in a dry place, avoiding bathrooms and areas prone to moisture.
2. Keep all medications in a secure location, out of the reach of children and pets.
3. Dispose of unused or expired medications properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so by your pharmacist.
4. Check with your pharmacist for guidance on the best way to dispose of your medication. You may also want to explore drug take-back programs in your area.
What to Do If You Miss a Dose
If you take your medication on a regular schedule:
1. Take a missed dose as soon as you remember.
2. If it's close to the time for your next dose, skip the missed dose and resume your regular schedule.
3. Do not take two doses at the same time or take extra doses.
If you take your medication as needed, follow your doctor's instructions and do not take it more frequently than recommended.
Lifestyle & Tips
- Drink plenty of fluids throughout the day to help the medication work effectively and prevent dehydration.
- Increase fiber intake in your diet (fruits, vegetables, whole grains) unless advised otherwise by your doctor.
- Engage in regular physical activity to promote bowel regularity.
- Do not use for more than 7 days unless directed by a doctor.
Available Forms & Alternatives
Available Strengths:
Dosing & Administration
Adult Dosing
Standard Dose:
17 grams (one heaping capful) of powder dissolved in 4 to 8 ounces of water, juice, soda, coffee, or tea once daily
Dose Range:
17 - 17 mg
Condition-Specific Dosing:
chronic_constipation:
May be used daily for up to 7 days, or as directed by a healthcare professional for longer periods.
Pediatric Dosing
Neonatal:
Not established (use only under medical supervision)
Infant:
Not established (use only under medical supervision)
Child:
For children 6 months to 16 years, dosing is typically off-label and should be guided by a physician, often 0.2 to 0.8 g/kg/day. For children 17 years and older, adult dosing (17g daily) may be used.
Adolescent:
For adolescents 17 years and older, 17 grams once daily. For younger adolescents (12-16 years), use under medical supervision, often 17g daily.
Dose Adjustments
Renal Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Dialysis:
No adjustment needed; minimal systemic absorption
Hepatic Impairment:
Mild:
No adjustment needed
Moderate:
No adjustment needed
Severe:
No adjustment needed
Pharmacology
Mechanism of Action
Polyethylene Glycol 3350 is an osmotic laxative. It is an inert, non-absorbable, osmotically active polymer that causes water to be retained within the bowel lumen. This increases the water content of the stool, leading to increased stool bulk, softened stool consistency, and increased stool frequency.
Pharmacokinetics
Absorption:
Bioavailability:
<0.2%
Tmax:
Not applicable (minimal systemic absorption)
FoodEffect:
None known; can be mixed with various beverages
Distribution:
Vd:
Not applicable (minimal systemic absorption)
ProteinBinding:
Not applicable (minimal systemic absorption)
CnssPenetration:
No
Elimination:
HalfLife:
Not applicable (minimal systemic absorption)
Clearance:
Not applicable (minimal systemic absorption)
ExcretionRoute:
Fecal (excreted unchanged)
Unchanged:
>99%
Pharmacodynamics
OnsetOfAction:
1 to 3 days
PeakEffect:
Not applicable (gradual effect over days)
DurationOfAction:
Maintains effect as long as therapy continues
Safety & Warnings
Side Effects
Urgent Side Effects: Seek Medical Help Right Away
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe dizziness or fainting
Diarrhea
Rectal bleeding or rectal pain
Other Possible Side Effects
Like all medications, this drug can cause side effects. Although many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or persist, contact your doctor for guidance:
Loose, watery, or more frequent stools
Stomach pain or cramps
Gas
Bloating
* Upset stomach
Reporting Side Effects
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
While rare, some people may experience severe and potentially life-threatening side effects when taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:
Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Severe dizziness or fainting
Diarrhea
Rectal bleeding or rectal pain
Other Possible Side Effects
Like all medications, this drug can cause side effects. Although many people may not experience any side effects or only minor ones, it's essential to discuss any concerns with your doctor. If you experience any of the following side effects or any other symptoms that bother you or persist, contact your doctor for guidance:
Loose, watery, or more frequent stools
Stomach pain or cramps
Gas
Bloating
* Upset stomach
Reporting Side Effects
This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, consult your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.
Seek Immediate Medical Attention If You Experience:
- Severe abdominal pain or cramping
- Nausea or vomiting
- Rectal bleeding
- No bowel movement after 3 days of use
- Signs of an allergic reaction (e.g., rash, itching, swelling, severe dizziness, trouble breathing)
Before Using This Medicine
Before Taking This Medication: Important Information to Share with Your Doctor
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
Certain health conditions, including:
+ Bowel obstruction or blockage
+ Abdominal pain
+ Upset stomach
+ Rectal bleeding
+ Vomiting
+ Changes in bowel habits that last longer than 2 weeks
A diagnosis of irritable bowel syndrome
Kidney disease or any other health problems that may interact with this medication
Additionally, provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter medications you are taking
Natural products and vitamins you are using
* Any health problems you have
This information is crucial to ensure your safety while taking this medication. Do not start, stop, or change the dose of any medication without first consulting your doctor to confirm that it is safe to do so.
It is essential to inform your doctor about the following:
Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
Certain health conditions, including:
+ Bowel obstruction or blockage
+ Abdominal pain
+ Upset stomach
+ Rectal bleeding
+ Vomiting
+ Changes in bowel habits that last longer than 2 weeks
A diagnosis of irritable bowel syndrome
Kidney disease or any other health problems that may interact with this medication
Additionally, provide your doctor and pharmacist with a comprehensive list of:
All prescription and over-the-counter medications you are taking
Natural products and vitamins you are using
* Any health problems you have
This information is crucial to ensure your safety while taking this medication. Do not start, stop, or change the dose of any medication without first consulting your doctor to confirm that it is safe to do so.
Precautions & Cautions
It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. Do not exceed the recommended duration of use, which is 1 week, unless your doctor specifically instructs you to do so. Additionally, refrain from using other laxatives or stool softeners concurrently with this drug, unless advised by your doctor. You may need to wait a few days to experience the full effects of the medication. If you are pregnant, planning to become pregnant, or are currently breastfeeding, be sure to discuss this with your doctor, as you will need to carefully weigh the benefits and risks of using this medication to ensure the well-being of both you and your baby.
Overdose Information
Overdose Symptoms:
- Severe diarrhea
- Excessive fluid loss
- Electrolyte imbalances (e.g., low potassium, low sodium)
- Abdominal distension
- Nausea
- Vomiting
What to Do:
Discontinue use. Provide supportive care, including fluid and electrolyte replacement as needed. In case of severe symptoms or suspected overdose, seek immediate medical attention or call a poison control center (1-800-222-1222).
Drug Interactions
Minor Interactions
- Other oral medications (potential for reduced absorption if taken simultaneously, though generally not clinically significant due to PEG's minimal systemic effect)
Monitoring
Routine Monitoring
Bowel movement frequency and consistency
Frequency: Daily during initial treatment, then as needed
Target: Regular, soft, formed stools
Action Threshold: No bowel movement after 3 days of use, or worsening constipation, abdominal pain, or bloating
Hydration status
Frequency: Daily
Target: Adequate fluid intake
Action Threshold: Signs of dehydration (e.g., dry mouth, decreased urination)
Symptom Monitoring
- Abdominal pain
- Bloating
- Nausea
- Diarrhea
- Rectal bleeding
- Signs of allergic reaction (rash, itching, swelling)
Special Patient Groups
Pregnancy
Generally considered safe due to minimal systemic absorption. Consult a healthcare provider before use.
Trimester-Specific Risks:
First Trimester:
Low risk due to minimal absorption.
Second Trimester:
Low risk due to minimal absorption.
Third Trimester:
Low risk due to minimal absorption.
Lactation
Considered safe for use during breastfeeding due to minimal systemic absorption by the mother, making infant exposure unlikely.
Infant Risk:
Low risk
Pediatric Use
Often used off-label for chronic constipation in children under medical supervision. Dosing must be individualized by a physician. For occasional constipation, generally not recommended for children under 17 without medical advice.
Geriatric Use
Generally safe for older adults. Start with the recommended dose and monitor for hydration and electrolyte balance, especially if other medical conditions or medications are present. No dose adjustment typically needed.
Clinical Information
Clinical Pearls
- PEG 3350 is a first-line osmotic laxative for chronic constipation due to its efficacy and good tolerability profile.
- It is not for immediate relief; expect bowel movement within 1 to 3 days.
- Ensure adequate fluid intake when using PEG 3350 to maximize its effect and prevent dehydration.
- Can be mixed with a variety of hot or cold beverages without affecting its efficacy.
- Unlike stimulant laxatives, PEG 3350 is generally not associated with tolerance or dependence with long-term use, making it suitable for chronic management under medical guidance.
Alternative Therapies
- Other osmotic laxatives (e.g., lactulose, magnesium hydroxide, magnesium citrate)
- Bulk-forming laxatives (e.g., psyllium, methylcellulose)
- Stool softeners (e.g., docusate sodium)
- Stimulant laxatives (e.g., bisacodyl, senna) - generally for short-term use
- Guanylate cyclase-C agonists (e.g., linaclotide, plecanatide) - for chronic idiopathic constipation or IBS-C
- Chloride channel activators (e.g., lubiprostone) - for chronic idiopathic constipation or IBS-C
Cost & Coverage
Average Cost:
Typically $10-$30 per 255g or 510g bottle
Generic Available:
Yes
Insurance Coverage:
Often not covered by insurance as it is an OTC product, but may be covered with a prescription for certain conditions or plans.
General Drug Facts
If your symptoms or health issues persist or worsen, it is essential to contact your doctor promptly. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so it's a good idea to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When reporting the incident, be prepared to provide details about the medication taken, the amount, and the time it occurred.