Aspirin 300mg Suppositories 12's

Aspirin (acetylsalicylic acid) irreversibly inhibits cyclooxygenase (COX-1 and COX-2) enzymes by acetylation. This prevents the synthesis of prostaglandins (mediators of pain, fever, and inflammation) and thromboxane A2 (a potent platelet aggregator). The antiplatelet effect is due to irreversible inhibition of COX-1 in platelets, which lack the ability to synthesize new enzyme.

Serious Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor or seek immediate medical attention:

Signs of an allergic reaction, such as:
+ Rash
+ Hives
+ Itching
+ Red, swollen, blistered, or peeling skin with or without fever
+ Wheezing
+ Tightness in the chest or throat
+ Trouble breathing, swallowing, or talking
+ Unusual hoarseness
+ Swelling of the mouth, face, lips, tongue, or throat
Signs of bleeding, such as:
+ Vomiting or coughing up blood
+ Vomit that resembles coffee grounds
+ Blood in the urine
+ Black, red, or tarry stools
+ Bleeding from the gums
+ Abnormal vaginal bleeding
+ Unexplained bruises or bruises that enlarge
+ Uncontrollable bleeding
Signs of kidney problems, such as:
+ Inability to urinate
+ Changes in urine output
+ Blood in the urine
+ Sudden significant weight gain
Signs of liver problems, such as:
+ Dark urine
+ Fatigue
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Signs of high potassium levels, such as:
+ Abnormal heartbeat
+ Confusion
+ Weakness, lightheadedness, or dizziness
+ Feeling faint
+ Numbness or tingling
+ Shortness of breath
Signs of acidosis (too much acid in the blood), such as:
+ Confusion
+ Rapid breathing
+ Rapid heartbeat
+ Abnormal heartbeat
+ Severe stomach pain, upset stomach, or vomiting
+ Excessive sleepiness
+ Shortness of breath
+ Feeling extremely tired or weak
Weakness on one side of the body
Difficulty speaking or thinking
Changes in balance
Drooping on one side of the face
Blurred vision
Severe dizziness or fainting
Severe headache
Ringing in the ears, hearing loss, or other changes in hearing
Feeling agitated
Seizures
Rectal bleeding or rectal pain

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild side effects. If you notice any of the following side effects or any other side effects that bother you or do not go away, contact your doctor or seek medical help:

Rectal irritation

This is not an exhaustive list of all possible side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Describe the allergic reaction and its symptoms.
Certain health conditions, including:
+ Asthma
+ Bleeding problems
+ Nose polyps or nose irritation
+ Kidney disease or liver disease
+ Gastrointestinal (GI) bleeding or ulcer disease
If you are taking another medication that contains the same active ingredient as this drug.
If you are taking any other nonsteroidal anti-inflammatory drugs (NSAIDs).
If you are pregnant, planning to become pregnant, or become pregnant while taking this medication. This drug may harm an unborn baby if taken after 20 weeks of pregnancy. Only take this medication after 20 weeks of pregnancy if your doctor has instructed you to do so.
If you are breastfeeding or plan to breastfeed.

Special Considerations for Children:

If the patient is a child, as this medication may not be suitable for all age groups.
If your child or teenager has or is recovering from flu symptoms, chickenpox, or other viral infections. The risk of Reye's syndrome, a severe condition, may be increased. Do not give this medication to a child or teenager with a viral infection or who is recovering from one.

Additional Important Information:

This list is not exhaustive, and it is crucial to inform your doctor and pharmacist about all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, as well as any health problems. This will help ensure your safety while taking this medication. Never start, stop, or change the dose of any medication without consulting your doctor.

It is essential to inform all of your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

To minimize the risk of severe side effects, it is crucial to adhere to the prescribed dosage and not exceed the recommended amount. Additionally, do not take this medication for longer than the duration specified by your doctor.

If you are taking this drug on a regular basis, do not discontinue use without first consulting the doctor who prescribed it for you. This medication may increase your risk of bleeding, so it is essential to take precautions to avoid injury. Use a soft-bristled toothbrush and an electric razor to minimize the risk of bleeding.

Before consuming alcohol, discuss the potential risks with your doctor. If you smoke, it is also important to talk with your doctor about the potential interactions between smoking and this medication.

This drug may increase the risk of severe and potentially life-threatening stomach or bowel problems, including ulcers or bleeding. This risk is higher in older adults, particularly those who have a history of stomach or bowel ulcers or bleeding. These complications can occur without warning signs, so it is essential to be aware of the potential risks.

If you are over 60 years old, use this medication with caution, as you may be more susceptible to side effects. Your doctor will carefully weigh the benefits and risks of this medication to determine the best course of treatment for your specific condition.

• Methotrexate (high-dose, >15 mg/week): Increased methotrexate toxicity due to displacement from protein binding and reduced renal clearance.
• Ketorolac (other NSAIDs): Increased risk of GI bleeding and renal impairment.
• Live attenuated influenza vaccine (LAIV) in children/adolescents: Risk of Reye's Syndrome if aspirin is given within 4 weeks of vaccination.

• Anticoagulants (e.g., Warfarin, Heparin, Dabigatran, Rivaroxaban): Increased risk of bleeding.
• Other NSAIDs (e.g., Ibuprofen, Naproxen, Celecoxib): Increased risk of GI bleeding, ulceration, and renal impairment. Ibuprofen may interfere with aspirin's antiplatelet effect.
• Corticosteroids (e.g., Prednisone): Increased risk of GI ulceration and bleeding. May also reduce salicylate levels.
• SSRIs/SNRIs (e.g., Fluoxetine, Sertraline): Increased risk of GI bleeding.
• Alcohol: Increased risk of GI bleeding.
• Sulfonylureas (e.g., Glyburide): Enhanced hypoglycemic effect.
• Valproic acid: Increased valproic acid levels due to protein binding displacement.
• Spironolactone, Furosemide (Diuretics): Reduced diuretic and antihypertensive effects; increased risk of renal impairment.
• ACE inhibitors/ARBs: Reduced antihypertensive effect; increased risk of renal impairment and hyperkalemia.

• Antacids/Urinary alkalinizers: Increased renal excretion of salicylates, potentially reducing efficacy.
• Probenecid, Sulfinpyrazone: Reduced uricosuric effect.
• Phenytoin: Increased phenytoin levels.
• Thyroid hormones: Aspirin may displace thyroid hormones from protein binding.

• Not available

• Gastrointestinal upset (heartburn, nausea, indigestion)
• Abdominal pain
• Black, tarry stools (melena)
• Vomiting blood (hematemesis)
• Unusual bruising or bleeding (e.g., nosebleeds, gum bleeding)
• Tinnitus (ringing in the ears)
• Hearing loss
• Dizziness
• Confusion
• Rapid breathing (hyperventilation)
• Rash or itching
• Swelling (edema)

Generally avoided, especially in the third trimester. Category D in the third trimester due to potential for premature closure of the fetal ductus arteriosus, persistent pulmonary hypertension of the newborn, and inhibition of labor. Use in early pregnancy should only be if clearly needed and benefits outweigh risks.

Aspirin and its metabolite, salicylic acid, are excreted into breast milk. Low doses (e.g., 75-150 mg/day) are generally considered compatible with breastfeeding, but caution is advised. High doses or chronic use should be avoided due to potential for adverse effects in the infant (e.g., metabolic acidosis, bleeding, Reye's Syndrome risk if infant has viral illness).

Contraindicated for fever or viral illness in children and teenagers due to the risk of Reye's Syndrome. Use for specific conditions (e.g., Kawasaki disease, juvenile idiopathic arthritis) is highly specialized and requires strict medical supervision.

Increased risk of adverse effects, particularly gastrointestinal bleeding, renal impairment, and fluid retention. Use the lowest effective dose for the shortest duration. Monitor renal function and for signs of GI bleeding.

• Aspirin suppositories are useful for patients who cannot tolerate oral medications due to nausea, vomiting, or dysphagia.
• Rectal absorption of aspirin can be variable and slower than oral, leading to less predictable plasma levels.
• Always counsel patients and caregivers about the risk of Reye's Syndrome when considering aspirin for children or teenagers, especially during viral illnesses.
• Be vigilant for signs of gastrointestinal bleeding, especially in elderly patients or those with a history of ulcers.
• Tinnitus is a common early sign of salicylate toxicity (salicylism) and warrants dose reduction or discontinuation.
• Aspirin's antiplatelet effect is irreversible and lasts for the lifetime of the platelet (7-10 days), which is important to consider before surgery.

• Acetaminophen (for pain and fever, no anti-inflammatory or antiplatelet effect, generally safer for children with viral illness).
• Other NSAIDs (e.g., Ibuprofen, Naproxen - for pain, fever, inflammation; reversible COX inhibition, generally not recommended for children with viral illness).
• Opioid analgesics (for severe pain, different mechanism of action, higher risk of dependence and side effects).

If your symptoms or health issues persist or worsen, it is essential to contact your doctor for further evaluation and guidance. To ensure safe and effective treatment, never share your medication with others or take someone else's medication. Some medications may have additional patient information leaflets, so it is a good idea to consult with your pharmacist for more information. If you have any questions or concerns about this medication, do not hesitate to discuss them with your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek emergency medical attention. When seeking help, be prepared to provide detailed information about the overdose, including the type and amount of medication taken, as well as the time it was taken.