Amox-Clav 250mg/5ml Susp 100ml

Amoxicillin is a bactericidal beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs), thereby interfering with the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall. This leads to inhibition of cell wall biosynthesis and eventually to bacterial cell lysis. Clavulanate potassium is a beta-lactamase inhibitor that protects amoxicillin from degradation by many beta-lactamase enzymes commonly produced by resistant bacteria. It binds irreversibly to beta-lactamase enzymes, preventing them from inactivating amoxicillin.

Urgent Side Effects: Seek Medical Help Right Away

Although rare, some people may experience severe and potentially life-threatening side effects while taking this medication. If you notice any of the following symptoms, contact your doctor immediately or seek emergency medical attention:

Signs of an allergic reaction, such as:
+ Rash or hives
+ Itching or red, swollen, blistered, or peeling skin (with or without fever)
+ Wheezing or tightness in the chest or throat
+ Difficulty breathing, swallowing, or talking
+ Unusual hoarseness or swelling of the mouth, face, lips, tongue, or throat
Rarely, allergic reactions can be fatal.
Signs of drug-induced enterocolitis syndrome, a type of allergic reaction, such as:
+ Vomiting within 1 to 4 hours after taking this medication
+ Diarrhea within 24 hours after taking this medication
+ Pale or gray skin
+ Feeling tired or unwell
+ Signs of low blood pressure, including severe dizziness or fainting
Vaginal irritation or discharge
Fever or chills
Unexplained bruising or bleeding
Diarrhea is a common side effect of antibiotics. However, in rare cases, a severe form called C. diff-associated diarrhea (CDAD) may occur, which can lead to life-threatening bowel problems. If you experience:
+ Stomach pain or cramps
+ Very loose, watery, or bloody stools
+ Contact your doctor immediately. Do not treat diarrhea without consulting your doctor first.
Liver problems, which can be fatal, have been reported with this medication. Seek medical attention immediately if you experience:
+ Dark urine
+ Fatigue
+ Decreased appetite
+ Upset stomach or stomach pain
+ Light-colored stools
+ Vomiting
+ Yellow skin or eyes
Severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious reactions, can occur with this medication. These reactions can be fatal and may affect other organs. Seek medical help immediately if you experience:
+ Red, swollen, blistered, or peeling skin
+ Red or irritated eyes
+ Sores in your mouth, throat, nose, eyes, genitals, or skin
+ Fever
+ Chills
+ Body aches
+ Shortness of breath
+ Swollen glands

Other Possible Side Effects

Like all medications, this drug can cause side effects. Many people may not experience any side effects or may only have mild ones. If you are concerned about any side effects or if they persist, contact your doctor or seek medical attention:

Common side effects for all patients taking this medication:
+ Diarrhea
+ Upset stomach
+ Vomiting
* Common side effects in children:
+ Diaper rash

Reporting Side Effects

This list is not exhaustive, and you may experience other side effects. If you have questions or concerns about side effects, contact your doctor. You can also report side effects to the FDA at 1-800-332-1088 or online at https://www.fda.gov/medwatch.

Before Taking This Medication: Important Information to Share with Your Doctor

It is essential to inform your doctor about the following conditions to ensure safe treatment:

Any allergies you have, including allergies to this medication, its components, or other substances, such as foods or drugs. Be sure to describe the allergic reaction and its symptoms.
If you are allergic to penicillin, as this may affect your ability to take this medication.
Existing kidney disease, as this may impact the medication's effectiveness or increase the risk of side effects.
Previous experiences with liver problems or jaundice (turning yellow) while taking this medication.
If you have been diagnosed with mononucleosis (mono), as this may require special consideration.
If you are currently taking probenecid, as this may interact with the medication.

This list is not exhaustive, and it is crucial to discuss all your medications, including prescription and over-the-counter drugs, natural products, and vitamins, with your doctor and pharmacist. They will help you determine if it is safe to take this medication in combination with your other treatments and health conditions. Never start, stop, or adjust the dosage of any medication without consulting your doctor first.

It is essential to inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking this medication. If you are taking this drug for an extended period, your doctor may recommend regular blood tests to monitor your condition.

This medication may interfere with certain laboratory tests, so it is crucial to notify all your healthcare providers and lab personnel that you are taking this drug. If you have diabetes and test your urine glucose levels, consult with your doctor to determine the most suitable tests to use.

Individuals with phenylketonuria (PKU) should discuss this condition with their doctor, as some products may contain phenylalanine.

Do not take this medication for longer than prescribed, as this may increase the risk of a second infection. A common side effect of this drug is a change in tooth color to yellow-gray-brown, which is more frequently reported in children. In most cases, the discoloration lessens or disappears with regular brushing or dental cleaning. If you notice any changes in tooth color, consult with your doctor.

When taking this medication, birth control pills and other hormone-based birth control methods may be less effective in preventing pregnancy. To minimize the risk of unplanned pregnancy, use an additional form of birth control, such as a condom, while taking this drug.

If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor. It is necessary to discuss the potential benefits and risks of this medication to both you and your baby.

• Methotrexate (increased methotrexate levels and toxicity)
• Warfarin (increased INR and bleeding risk)

• Allopurinol (increased incidence of rash)
• Oral Contraceptives (potential for reduced efficacy, though evidence is mixed)
• Probenecid (increases amoxicillin levels by decreasing renal tubular secretion)
• Mycophenolate mofetil (reduced mycophenolate exposure)

• Typhoid vaccine (live, oral) (may reduce therapeutic effect of vaccine)

• Rash
• Itching
• Hives
• Swelling of face/lips/tongue
• Difficulty breathing
• Severe or persistent diarrhea
• Abdominal pain
• Nausea
• Vomiting
• Yellowing of skin or eyes (jaundice)
• Dark urine
• Unusual tiredness or weakness

Generally considered safe for use during pregnancy (Category B). Studies in animals have not shown harm to the fetus, and there is no evidence of harm in human studies. However, use only if clearly needed.

Considered compatible with breastfeeding (L1). Both amoxicillin and clavulanate are excreted in small amounts into breast milk. Monitor infant for potential adverse effects such as diarrhea, candidiasis (thrush), or allergic reactions (rash).

Dosing is weight-based and depends on the severity and type of infection. The 250mg/5ml suspension is commonly used for pediatric patients. Close monitoring for gastrointestinal side effects and rash is important. Not recommended for neonates (under 12 weeks) due to immature renal function.

No specific dose adjustment based solely on age, but dose should be adjusted for renal impairment, which is more common in the elderly. Increased risk of adverse effects, particularly gastrointestinal and hepatic, should be considered. Monitor liver and kidney function.

• Always instruct patients to shake the suspension well before each use and to use the provided measuring device.
• Advise patients to take the medication at the start of a meal to minimize GI upset and enhance clavulanate absorption.
• Emphasize the importance of completing the full course of therapy, even if symptoms improve, to prevent resistance.
• Counsel patients on the signs and symptoms of C. difficile-associated diarrhea and the need to seek medical attention if it occurs.
• Be aware of the potential for drug-induced liver injury, especially with prolonged use or in patients with pre-existing liver conditions, though it is rare.

• Cephalexin (Keflex)
• Cefdinir (Omnicef)
• Azithromycin (Zithromax)
• Clindamycin (Cleocin)
• Doxycycline (Vibramycin)

If your symptoms or health issues persist or worsen, it's essential to contact your doctor for further guidance. To ensure your safety, never share your medication with others or take someone else's medication. Some medications may come with an additional patient information leaflet, so be sure to check with your pharmacist for more information. If you have any questions or concerns about this medication, don't hesitate to reach out to your doctor, nurse, pharmacist, or other healthcare provider. In the event of a suspected overdose, immediately call your local poison control center or seek medical attention. When seeking help, be prepared to provide details about the medication, including the amount taken and the time it happened, to facilitate prompt and effective treatment.